ArticleEpilepsia2016
Age-dependent mesial temporal lobe lateralization in language fMRI.
Article in Epilepsia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Commonality and Variability in Functional Networks in Children Under 5 Years Old.bioRxiv : the preprint server for biology · 2026Article
- Neural (re)organisation of language and memory: implications for neuroplasticity and cognition.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Mapping Cognition in Epilepsy: From the Lab to the Clinic.Epilepsy currents · 2024Review
- Occupation-modulated language networks and its lateralization: A resting-state fMRI study of seafarers.Frontiers in human neuroscience · 2023Article
- Article
- Highlights From AES2020, a Virtual American Epilepsy Society Experience.Epilepsy currents · 2021Article
- Effect of corpus callosum agenesis on the language network in children and adolescents.Brain structure & function · 2021Article
- The role of the corpus callosum in language network connectivity in children.Developmental science · 2021Article
- Establishing a Developmentally Appropriate fMRI Paradigm Relevant to Presurgical Mapping of Memory in Children.Brain topography · 2020Article
- Advanced neuroimaging techniques for evaluating pediatric epilepsy.Clinical and experimental pediatrics · 2020Article
- Absence of neural speech discrimination in preterm infants at term-equivalent age.Developmental cognitive neuroscience · 2019Article
- fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters.Epilepsia · 2019Article
- Atypical language representation is unfavorable for language abilities following childhood stroke.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2019Article
- A Functional MRI Paradigm Suitable for Language and Memory Mapping in Pediatric Temporal Lobe Epilepsy.Frontiers in neurology · 2019Article
- Imaging episodic memory during development and childhood epilepsy.Journal of neurodevelopmental disorders · 2018Review
- Weaker semantic language lateralization associated with better semantic language performance in healthy right-handed children.Brain and behavior · 2018Article
- When two are better than one: Bilateral mesial temporal lobe contributions associated with better vocabulary skills in children and adolescents.Brain and language · 2018Article
- Mens inversus in corpore inverso? Language lateralization in a boy with situs inversus totalis.Brain and language · 2017Article
- Language functional MRI and direct cortical stimulation in epilepsy preoperative planning.Annals of neurology · 2017Article
- Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries.eLife · 2017Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveFunctional magnetic resonance imaging (fMRI) activation of the mesial temporal lobe (MTL) may be important for epilepsy surgical planning. We examined MTL activation and lateralization during language fMRI in children and adults with focal epilepsy.
methodsOne hundred forty-two controls and patients with left hemisphere focal epilepsy (pediatric: epilepsy, n = 17, mean age = 9.9 ± 2.0; controls, n = 48; mean age = 9.1 ± 2.6; adult: epilepsy, n = 20, mean age = 26.7 ± 5.8; controls, n = 57, mean age = 26.2 ± 7.5) underwent 3T fMRI using a language task (auditory description decision task). Image processing and analyses were conducted using Statistical Parametric Mapping (SPM8); regions of interest (ROIs) included MTL, Broca's area, and Wernicke's area. We assessed group and individual MTL activation, and examined degree of lateralization.
resultsPatients and controls (pediatric and adult) demonstrated group and individual MTL activation during language fMRI. MTL activation was left lateralized for adults, but less so in children (p's < 0.005). Patients did not differ from controls in either age group. Stronger left-lateralized MTL activation was related to older age (p = 0.02). Language lateralization (Broca's and Wernicke's) predicted 19% of the variance in MTL lateralization for adults (p = 0.001), but for not children. SIGNIFICANCE: Language fMRI may be used to elicit group and individual MTL activation. The developmental difference in MTL lateralization and its association with language lateralization suggests a developmental shift in lateralization of MTL function, with increased left lateralization across the age span. This shift may help explain why children have better memory outcomes following resection compared to adults.
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