Evidence map›Paper›PMID 26696531›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Kono-S Anastomosis for Surgical Prophylaxis of Anastomotic Recurrence in Crohn's Disease: an International Multicenter Study.

Toru Kono, Alessandro Fichera, Koutarou Maeda, Yoshiharu Sakai, Hiroki Ohge, Mukta Krane, Hidetoshi Katsuno, Mikihiro Fujiya

2 registry-linked trialsAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 61 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 5 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04578392 naterminatednot on this mapstarted 2020, after this paper: background citation

MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)

TypeinterventionalSponsorThe Cleveland ClinicRan2020 to 2023Enrolled13ConditionsCrohn DiseaseArmshigh ligation of ileocolic artery, mesenteric sparing
NCT07231601 recruitingnot on this mapstarted 2022, after this paper: background citation

Laparoscopic Mesenteric Excision and Exclusion for Crohn's Disease of the Terminal Ileum. A Greek Single Center Study.

Typeobservational_patient_registrySponsorTzaneio General HospitalRan2022 to 2032Enrolled50ConditionsCrohn Disease (CD), Crohn Disease of Ileum, Kono S Anastomosis, Extended Mesenteric ExcisionArmsMesenteric excision and exclusion
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Pooled it
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  17. Bowel Resection Margins in Crohn's Disease: Do They Matter?Clinics in colon and rectal surgery · 2025
    Review
  18. Article
  19. Management of inflammatory bowel disease in the emergency setting: the MIBODI international survey and evidence-based practices.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Toru KonoAdvanced Surgery Center, Sapporo Higashi Tokushukai Hospital, 3-1, N 33, E 14, Higashi-ku, Sapporo, Hokkaido, 065-0033, Japan. kono@toru-kono.com.
Alessandro FicheraDivision of General Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA.
Koutarou MaedaDepartment of Surgery, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Yoshiharu SakaiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroki OhgeDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan.
Mukta KraneDivision of General Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA.
Hidetoshi KatsunoDepartment of Surgery, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Mikihiro FujiyaDivision of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.
Fujita Health University · JPUniversity of Washington Medical Center · USAsahikawa Medical University · JPHiroshima University Hospital · JPKyoto University · JPSapporo Higashi Tokushukai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Kono-S (antimesenteric functional end-to-end handsewn) anastomosis has been used for Crohn's disease in Japan and the USA since 2003 and 2010, respectively. This technique was designed to reduce the risk of anastomotic surgical recurrence. This study reviews the outcomes a decade after the introduction of the Kono-S anastomosis to clinical practice.

methodsThis study was conducted at five hospitals (four in Japan and one in the USA). A total of 187 patients in Japan (144 patients, group J) and the USA (43 patients, group US) who underwent Kono-S anastomosis for Crohn's disease between September 2003 and September 2011 were included.

resultsWith a median follow-up of 65 months, two surgical anastomotic recurrences have occurred in group J. Kaplan-Meier analysis showed that 5 and 10 years surgical recurrence-free survival rate was 98.6% in group J. No surgical anastomotic recurrences have been detected in group US with a median follow-up of 32 months. The Kono-S anastomosis was technically feasible and performed in all patients.

conclusionThe Kono-S anastomosis appears to be safe and effective in reducing the risk of surgical recurrence in Crohn's disease.

Indexed as

AdolescentAdultAnastomosis, SurgicalColonCrohn DiseaseDisease-Free SurvivalFemaleFollow-Up StudiesHumansIleumJapanKaplan-Meier EstimateMaleMiddle AgedRecurrenceRetrospective StudiesCrohn’s diseaseKono-S anastomosisSurgical recurrence

Identifiers

PMID26696531
OpenAlexW2212173009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.