ArticlePloS one2015
Change in Dengue and Japanese Encephalitis Seroprevalence Rates in Sri Lanka.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Neutralizing Antibody Correlates Analysis of Tetravalent Dengue Vaccine Efficacy Trials in Asia and Latin America.The Journal of infectious diseases · 2018Trial
- Dissecting Age-Stratified Immunity to Different Dengue Virus Serotypes and Zika Viruses Among Children in a Highly Endemic Region in Sri Lanka.Open forum infectious diseases · 2026Article
- Epidemiological burden of dengue in Sri Lanka: A systematic review of literature from 2000-2020.IJID regions · 2024Review
- Is the rise in childhood obesity rates leading to an increase in hospitalizations due to dengue?PLoS neglected tropical diseases · 2024Article
- Article
- Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases.Viruses · 2022Review
- Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity.Vaccines · 2022Article
- Seroepidemiological Studies on Japanese Encephalitis: A Systematic Review.Oman medical journal · 2022Review
- Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago.Viruses · 2022Article
- The Burden of Acute Febrile Illness Attributable to Dengue Virus Infection in Sri Lanka: A Single-Center 2-Year Prospective Cohort Study (2016-2019).The American journal of tropical medicine and hygiene · 2021Article
- Changing epidemiology of dengue in Sri Lanka-Challenges for the future.PLoS neglected tropical diseases · 2021Review
- Emergence of Dengue 4 as Dominant Serotype During 2017 Outbreak in South India and Associated Cytokine Expression Profile.Frontiers in cellular and infection microbiology · 2021Article
- Climatological, virological and sociological drivers of current and projected dengue fever outbreak dynamics in Sri Lanka.Journal of the Royal Society, Interface · 2020Article
- Development and validation of an assay for detection of Japanese encephalitis virus specific antibody responses.PloS one · 2020Article
- Identification of Immune Responses to Japanese Encephalitis Virus Specific T Cell Epitopes.Frontiers in public health · 2020Article
- Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection.Nature communications · 2018Article
- Dengue seroprevalence in a cohort of schoolchildren and their siblings in Yucatan, Mexico (2015-2016).PLoS neglected tropical diseases · 2018Article
- Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review.PLoS neglected tropical diseases · 2018Article
- Seroprevalence of dengue IgG antibodies in symptomatic and asymptomatic individuals three years after an outbreak in Zhejiang Province, China.BMC infectious diseases · 2018Article
- Viral aetiologies of acute encephalitis in a hospital-based South Asian population.BMC infectious diseases · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundSri Lanka has been affected by epidemics of dengue infections for many decades and the incidence and severity of dengue infections have been rising each year. Therefore, we investigated the age stratified seroprevalence of dengue infections in order to facilitate future dengue vaccine strategies. In addition, since the symptomatic dengue infections have increased during the past few decades, we also investigated the possible association with Japanese Encephalitis Virus (JEV) antibody seropositivity with symptomatic dengue in a community cohort in Sri Lanka.
methods1689 healthy individuals who were attending a primary health care facility were recruited. Dengue and JEV antibody status was determined in all individuals and JEV vaccination status was recorded.
results1152/1689 (68.2%) individuals were seropositive for dengue and only 133/1152 (11.5%) of them had been hospitalized to due to dengue. A significant and positive correlation was observed for dengue antibody seropositivity and age in children (Spearmans R = 0.84, p = 0.002) and in adults (Spearmans R = 0.96, p = 0.004). We observed a significant rise in the age stratified seroprevalence rates in children over a period of 12 years. For instance, in year 2003 the annual seroconversion rate was 1.5% per annum, which had risen to 3.79% per annum by 2014. We also found that both adults (p<0.001) and in children (p = 0.03) who were hospitalized due to dengue were more likely to be seropositive for JEV antibodies. However, 244 (91.4%) of adults who were seropositive for JEV had not had the JEV vaccine.
conclusionsDengue seroprevalence rates have risen significantly over the last 12 years in Sri Lanka, possibly due to increased transmission. As individuals who were hospitalized due to dengue were more likely to be seropositive for JEV, the possibility of cross-reactive assays and/or of JEV infection on immunity to the DENV and clinical disease severity should be further investigated.
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