Evidence map›Paper›PMID 26696121›Full record

ArticleEndocrinology2016

Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia.

William P Cawthorn, Erica L Scheller, Sebastian D Parlee, H An Pham, Brian S Learman, Catherine M H Redshaw, Richard J Sulston, Aaron A Burr, Arun K Das, Becky R Simon and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024
    Pooled it
  3. Trial
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  8. Review
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  15. Calorie restriction in mice impairs cortical but not trabecular peak bone mass by suppressing bone remodeling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
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  17. Review
  18. Review
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

William P CawthornDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Erica L SchellerDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Sebastian D ParleeDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
H An PhamDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Brian S LearmanDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Catherine M H RedshawDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Richard J SulstonDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Aaron A BurrDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Arun K DasDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Becky R SimonDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Hiroyuki MoriDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Adam J BreeDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Benjamin SchellDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Venkatesh KrishnanDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
Ormond A MacDougaldDepartments of Molecular and Integrative Physiology (W.P.C., E.L.S., S.D.P., H.A.P., B.S.L., A.A.B., H.M., A.J.B., B.S., O.A.M.) and Internal Medicine (A.K.D., O.A.M.), and Program in Cellular and Molecular Biology (B.R.S., O.A.M.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Musculoskeletal Research (W.P.C., V.K.), Lilly Research Laboratories, Indianapolis, Indiana 46285; and University/British Heart Foundation Centre for Cardiovascular Science (W.P.C., C.M.H.R., R.J.S.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom EH16 4TJ.
University of Michigan–Ann Arbor · USThe Queen's Medical Research Institute · GB

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RANDY J SEELEY · 2010 to 2026
$20.3M
Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
TRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9M
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
Neural regulation of skeletal biology and periodontal disease progression in typeK99DE024178 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHELLER, ERICA LYNN · 2014 to 2015
$203k
Medical Research Council MR/M021394/1NCRR NIH HHS S10 RR026475NCRR NIH HHS S10-RR026475-01NICHD NIH HHS 5-T32-HD007505NICHD NIH HHS T32 HD007505NIDCR NIH HHS K99 DE024178NIDCR NIH HHS K99-DE024178NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R24 DK092759NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Bone marrow adipose tissue (MAT) accounts for up to 70% of bone marrow volume in healthy adults and increases further in clinical conditions of altered skeletal or metabolic function. Perhaps most strikingly, and in stark contrast to white adipose tissue, MAT has been found to increase during caloric restriction (CR) in humans and many other species. Hypoleptinemia may drive MAT expansion during CR but this has not been demonstrated conclusively. Indeed, MAT formation and function are poorly understood; hence, the physiological and pathological roles of MAT remain elusive. We recently revealed that MAT contributes to hyperadiponectinemia and systemic adaptations to CR. To further these observations, we have now performed CR studies in rabbits to determine whether CR affects adiponectin production by MAT. Moderate or extensive CR decreased bone mass, white adipose tissue mass, and circulating leptin but, surprisingly, did not cause hyperadiponectinemia or MAT expansion. Although this unexpected finding limited our subsequent MAT characterization, it demonstrates that during CR, bone loss can occur independently of MAT expansion; increased MAT may be required for hyperadiponectinemia; and hypoleptinemia is not sufficient for MAT expansion. We further investigated this relationship in mice. In females, CR increased MAT without decreasing circulating leptin, suggesting that hypoleptinemia is also not necessary for MAT expansion. Finally, circulating glucocorticoids increased during CR in mice but not rabbits, suggesting that glucocorticoids might drive MAT expansion during CR. These observations provide insights into the causes and consequences of CR-associated MAT expansion, knowledge with potential relevance to health and disease.

Indexed as

Caloric RestrictionAdipogenesisAdipose TissueAnimalsBone DensityBone MarrowFemaleGlucocorticoidsLeptinMaleMiceMice, Inbred C57BLOrgan SizeRabbitsGlucocorticoidsLeptin

Identifiers

PMID26696121
PMCPMC4733126
OpenAlexW2221677062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.