Evidence map›Paper›PMID 26696028›Full record

ArticleGut and liver2016

Mass Eradication of Helicobacter pylorito Prevent Gastric Cancer: Theoretical and Practical Considerations.

Yi-Chia Lee, Tsung-Hsien Chiang, Jyh-Ming Liou, Hsiu-Hsi Chen, Ming-Shiang Wu, David Y Graham

Registry-linked trialAbstract read
In one paragraph

Article in Gut and liver, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06216639 (EU4Health Project Eurohelican), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06216639 unknown statusnot on this mapstarted 2024, after this paper: background citation

EU4Health Project Eurohelican: A Single-center Prospective Feasibility Study of the Proposed Test-and-treat Preventive Screening Program in Younger Slovenian Participants Aged 30-34 Years With or Without Helicobacter Pylori Infection

TypeobservationalSponsorNational Institute of Public Health, SloveniaRan2024 to 2025Enrolled2,000ConditionsHelicobacter Pylori InfectionArmsBismuth Subcitrate, Esomeprazole, Metronidazole, Amoxicillin, Clarithromycin
3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A Malaysian consensus report on the diagnosis and treatment ofJGH open : an open access journal of gastroenterology and hepatology · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Biology · 2021
    Article
  10. Review
  11. The Anti-Visceral medicine · 2020
    Article
  12. Metronidazole-resistantNew microbes and new infections · 2020
    Article
  13. Update on the Management ofCurrent treatment options in gastroenterology · 2020
    Review
  14. Review
  15. Review
  16. Article
  17. Houston Consensus Conference on Testing for Helicobacter pylori Infection in the United States.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018
    Article
  18. Article
  19. Common Variable Immunodeficiency and Gastric Malignancies.International journal of molecular sciences · 2018
    Review
  20. Eradicating gastric cancer.JGH open : an open access journal of gastroenterology and hepatology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi-Chia LeeDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Tsung-Hsien ChiangDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Jyh-Ming LiouDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Hsiu-Hsi ChenInstitute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, Taipei, Taiwan.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
David Y GrahamDepartment of Medicine, Michael E. DeBakey VA Medical Center, and Baylor College of Medicine, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the age-adjusted incidence of gastric cancer is declining, the absolute number of new cases of gastric cancer is increasing due to population growth and aging. An effective strategy is needed to prevent this deadly cancer. Among the available strategies, screen-and-treat for Helicobacter pylori infection appears to be the best approach to decrease cancer risk; however, implementation of this strategy on the population level requires a systematic approach. The program also must be integrated into national healthcare priorities to allow the limited resources to be most effectively allocated. Implementation will require adoption of an appropriate screening strategy, an efficient delivery system with a timely referral for a positive test, and standardized treatment regimens based on clinical efficacy, side effects, simplicity, duration, and cost. Within the population, there are subpopulations that vary in risk such that a "one size fits all" approach is unlikely to be ideal. Sensitivity analyses will be required to identify whether the programs can be utilized by heterogeneous populations and will likely require adjustments to accommodate the needs of subpopulations.

Indexed as

Health PrioritiesHelicobacter InfectionsHelicobacter pyloriHumansMass ScreeningStomach NeoplasmsEradicationHelicobacter pyloriPopulation screeningStomach neoplasms

Identifiers

PMID26696028
PMCPMC4694730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.