Evidence map›Paper›PMID 26695766›Full record

ReviewMolecular & cellular proteomics : MCP2016

Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury.

Erna A van Niekerk, Mark H Tuszynski, Paul Lu, Jennifer N Dulin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular & cellular proteomics : MCP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  19. Article
  20. Long-Term Cultures of Spinal Cord Interneurons.Frontiers in cellular neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erna A van NiekerkFrom the ‡Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093; errrna@gmail.com.
Mark H TuszynskiFrom the ‡Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093; §Veterans Administration Medical Center, San Diego, CA 92161.
Paul LuFrom the ‡Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093; §Veterans Administration Medical Center, San Diego, CA 92161.
Jennifer N DulinFrom the ‡Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093;

Funding

Bioengineered Scaffolds for Spinal Cord InjuryR01EB014986 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAKAMOTO, JEFFREY, TUSZYNSKI, MARK H. · 2012 to 2016
$2.4M
MINORITY PREDOCTORAL FELLOWSHIP PROGRAM--NIGMSF31NS009881 · NINDS · UNIVERSITY OF TEXAS EL PASO · PI BOGGIANO, MARY M · 1994 to 1997
–
NIBIB NIH HHS EB014986NIBIB NIH HHS R01 EB014986NINDS NIH HHS F31 NS009881NINDS NIH HHS NS09881
6 · The paper itself

Abstract

Following axotomy, a complex temporal and spatial coordination of molecular events enables regeneration of the peripheral nerve. In contrast, multiple intrinsic and extrinsic factors contribute to the general failure of axonal regeneration in the central nervous system. In this review, we examine the current understanding of differences in protein expression and post-translational modifications, activation of signaling networks, and environmental cues that may underlie the divergent regenerative capacity of central and peripheral axons. We also highlight key experimental strategies to enhance axonal regeneration via modulation of intraneuronal signaling networks and the extracellular milieu. Finally, we explore potential applications of proteomics to fill gaps in the current understanding of molecular mechanisms underlying regeneration, and to provide insight into the development of more effective approaches to promote axonal regeneration following injury to the nervous system.

Indexed as

ProteomicsAxonsAxotomyCentral Nervous SystemHumansNeuronsProtein BiosynthesisProtein Processing, Post-TranslationalRegenerationSignal TransductionSpinal CordSpinal Cord Injuries

Identifiers

PMID26695766
PMCPMC4739663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.