Evidence map›Paper›PMID 26695753›Full record

ReviewAlcohol research : current reviews2015

Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival.

Gary G Meadows, Hui Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Alcohol research : current reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Chemokine Receptor-4 Targeted PET/CT Imaging withDiagnostics (Basel, Switzerland) · 2024
    Article
  14. Review
  15. Alcohol, Smoking, and Risks of Breast Cancer Recurrence and Mortality among Women with Luminal, Triple-Negative, and HER2-Overexpressing Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gary G MeadowsDepartment of Pharmaceutical Sciences at Washington State University, Spokane, Washington.
Hui ZhangDepartment of Pharmaceutical Sciences at Washington State University, Spokane, Washington.
Washington State University Spokane · US

Funding

Mechanistic efforts of chronic alcohol on tumor metastasis and survivalK05AA017149 · NIAAA · WASHINGTON STATE UNIVERSITY · PI MEADOWS, GARY G · 2008 to 2012
$1.1M
Immunotherapy to Mitigate the Negative Effects of Alcohol on Cancer ProgressionR21AA022098 · NIAAA · WASHINGTON STATE UNIVERSITY · PI ZHANG, HUI · 2014 to 2015
$391k
NIAAA NIH HHS K05-AA-017149NIAAA NIH HHS R21-AA-022098
6 · The paper itself

Abstract

Most research involving alcohol and cancer concerns the relationship between alcohol consumption and cancer risk and the mechanisms of carcinogenesis. This review relates the amount and duration of alcohol intake in humans and in animal models of cancer to tumor growth, angiogenesis, invasion, metastasis, immune response, and host survival in specific types and subtypes of cancer. Research on the influence of alcohol drinking on human cancer patients is limited. Although there is more information in animal models of cancer, many aspects still are ill defined. More research is needed to define the mechanisms that underlie the role of alcohol on cancer progression in both animals and humans. Activation of the immune system can play a positive role in keeping cancer under control, but this also can facilitate cancer progression. Additionally, a functional immune system is required for cancer patients to achieve an optimal response to conventional chemotherapy. Insight into the underlying mechanisms of these interactions could lead to effective immunotherapeutic approaches to treat alcoholics with cancer. Defining the epigenetic mechanisms that modulate cancer progression also has great potential for the development of new treatment options not only for treating alcoholics with cancer but also for treating other alcohol-induced diseases.

Indexed as

Gene Expression Regulation, NeoplasticAlcohol DrinkingAlcoholismAnimalsDisease Models, AnimalDisease ProgressionEpigenesis, GeneticHumansNeoplasm MetastasisNeoplasmsNeovascularization, PathologicSurvival RateTumor Escape

Identifiers

PMID26695753
PMCPMC4590626
OpenAlexW1419696866

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.