Evidence map›Paper›PMID 26695721›Full record

ArticleEuropean journal of clinical nutrition2016

Vitamin D status during fetal life and childhood kidney outcomes.

K Miliku, T Voortman, O H Franco, J J McGrath, D W Eyles, T H Burne, A Hofman, H Tiemeier, V W V Jaddoe

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Article in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Vitamin D and Glomerulonephritis.Medicina (Kaunas, Lithuania) · 2021
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

K MilikuThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-9614-7191
T VoortmanThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-2830-6813
O H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
J J McGrathQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
D W EylesQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
T H BurneQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
A HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
H TiemeierDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-4395-1397
V W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Funding

European Research Council 648916
6 · The paper itself

Abstract

BACKGROUND/

objectivesMaternal vitamin D deficiency during pregnancy may influence offspring kidney health. We aimed to examine the associations of 25-hydroxyvitamin D (25(OH)D) blood levels during fetal life with kidney outcomes at school age. SUBJECTS/

methodsThis study was embedded in a population-based prospective cohort study among 4212 mother-child pairs. We measured maternal second trimester (18-25 weeks) and fetal cord blood (at birth) 25(OH)D levels. At a median age of 6.0 years, we measured children's combined kidney volume, glomerular filtration rate (eGFR) from creatinine and cystatin C serum levels, and microalbuminuria from albumin and creatinine urine levels.

resultsOf all mothers, 21.9% had severely deficient levels (25(OH)D <25.0 nmol/l), 25.7% had deficient levels (25.0-49.9 nmol/l), 25% had sufficient levels (50.0-74.9 nmol/l) and 27.4% had optimal levels (⩾75.0 nmol/l). Maternal 25(OH)D levels were not consistently associated with childhood combined kidney volume. Higher maternal 25(OH)D levels were associated with lower childhood eGFR (difference -0.94 ml/min per 1.73 m(2) (95% confidence interval, -1.73; -0.15) per 1 standard deviation (s.d.) increase in 25(OH)D). Maternal 25(OH)D levels were not associated with microalbuminuria. Cord blood 25(OH)D levels were not associated with childhood kidney outcomes. The associations of maternal 25(OH)D levels with childhood eGFR were partly explained by childhood vitamin D status.

conclusionsOur findings suggest that maternal 25(OH)D levels during pregnancy may influence childhood kidney outcomes. These results should be considered hypothesis generating. Further studies are needed to replicate the observations, to examine the underlying mechanisms and to identify the long-term clinical consequences.

Indexed as

AdultChildFemaleFetal BloodHumansKidneyKidney Function TestsMaleMaternal Nutritional Physiological PhenomenaPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsProspective StudiesVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D

Identifiers

PMID26695721
PMCPMC5576536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.