ArticleAnnals of the American Thoracic Society2016
Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- An ACMT Network of Medical Toxicology Clinics (NMTC): A Proposed Collaboration of Medical Toxicologists to Meet National Emergency Preparedness Needs.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026Article
- Oxidative damage to lung mitochondrial DNA is a key contributor to the development of chemical lung injury.Redox biology · 2025Article
- Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Clinical Features and Outcomes of Acute Chlorine Gas Inhalation; a Brief Report.Archives of academic emergency medicine · 2022Article
- Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems.Physiology (Bethesda, Md.) · 2021Review
- Toxic effects of chlorine gas and potential treatments: a literature review.Toxicology mechanisms and methods · 2021Review
- Article
- Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury.Annals of the New York Academy of Sciences · 2020Review
- Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice.Journal of the American Heart Association · 2020Article
- Designing and executing a functional exercise to test a novel informatics tool for mass casualty triage.Journal of the American Medical Informatics Association : JAMIA · 2019Article
- Halogen Inhalation-Induced Lung Injury and Acute Respiratory Distress Syndrome.Chinese medical journal · 2018Review
- Chlorine Countermeasures: Supplemental Oxygen Equals Supplemental Lung Injury?American journal of respiratory cell and molecular biology · 2018Article
- An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.Annals of the American Thoracic Society · 2017Article
- Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation.Toxicology and applied pharmacology · 2017Article
- Persistent effects of chlorine inhalation on respiratory health.Annals of the New York Academy of Sciences · 2016Review
- Chlorine-induced cardiopulmonary injury.Annals of the New York Academy of Sciences · 2016Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
rationaleOn January 6, 2005 a train derailment led to an estimated 54,915-kg release of chlorine at a local textile mill in Graniteville, South Carolina.
objectivesWe used the employee health spirometry records of the textile to identify enduring effects of chlorine gas exposure resulting from the incident on the lung function of workers employed at the textile mill.
methodsSpirometry records from 1,807 mill workers (7,332 observations) were used from 4 years before and 18 months after the disaster. Longitudinal analysis using marginal regression models produced annual population mean estimates for FEV1, FVC, and FEV1/FVC ratio. Covariate adjustment was made for sex, age, smoking, height, season tested, technician, obesity, season × year interactions, and smoker × year interactions. The increased prevalence of mill workers having accelerated FEV1 decline was also evaluated after the chlorine spill. MEASUREMENTS AND MAIN
resultsIn the year of the accident, we observed a significant reduction in mean FEV1 (-4.2% predicted; P = 0.019) when compared with the year before the incident. In the second year, partial recovery in the mean FVC % predicted level was seen, but the cohort's average FEV1/FVC ratio continued to decrease over time. Severe annual FEV1 decline was most prevalent in the year of the accident, and independent of mill worker smoking status.
conclusionsThe Graniteville mill worker cohort revealed significant reductions in lung function immediately after the chlorine incident. Improvement was seen in the second year; but the proportion of mill workers experiencing accelerated FEV1 annual decline significantly increased in the 18 months after the chlorine incident.
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