ArticlePloS one2015
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response.Scientific reports · 2019Trial
- TransferGWAS of T1-weighted brain MRI data from UK Biobank.PLoS genetics · 2024Article
- Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease.International journal of molecular sciences · 2024Article
- A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes.Bone research · 2020Article
- Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study.Therapeutic advances in musculoskeletal disease · 2020Article
- Identifying potentially common genes between dyslipidemia and osteoporosis using novel analytical approaches.Molecular genetics and genomics : MGG · 2018Article
- Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.Annals of the rheumatic diseases · 2018Article
- A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics.American journal of human genetics · 2017Article
- Enhanced Identification of Potential Pleiotropic Genetic Variants for Bone Mineral Density and Breast Cancer.Calcified tissue international · 2017Article
- Article
- Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women.Epigenetics · 2017Article
- Article
- Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
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Authors and funding
15 authors.
Funding
Abstract
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity.
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