ArticleClinical cardiology2016
Statin Use and Aneurysm Risk in Patients With Bicuspid Aortic Valve Disease.
Article in Clinical cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.The Journal of thoracic and cardiovascular surgery · 2023Guideline
- Guideline
- 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2022Guideline
- A machine learning predictive model based on conventional two-dimensional echocardiography and serum biomarkers for early detection of ascending aorta dilation in BAV patients.Frontiers in cardiovascular medicine · 2026Article
- Medical therapy after surgical aortic valve replacement for aortic regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
- The need for comprehensive multidisciplinary programs, complex interventions, and precision medicine for bicuspid aortic valve disease.Annals of cardiothoracic surgery · 2022Review
- High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease.Nature genetics · 2022Article
- DNA Methylation Analysis of Turner Syndrome BAV.Frontiers in genetics · 2022Article
- Predictors of Ascending Aorta Enlargement and Valvular Dysfunction Progression in Patients with Bicuspid Aortic Valve.Journal of clinical medicine · 2021Article
- Aortic Dilatation in Patients With Bicuspid Aortic Valve.Frontiers in physiology · 2021Review
- Enlightening the Association between Bicuspid Aortic Valve and Aortopathy.Journal of cardiovascular development and disease · 2018Review
- Bicuspid Aortic Valvulopathy and Associated Aortopathy: a Review of Contemporary Studies Relevant to Clinical Decision-Making.Current treatment options in cardiovascular medicine · 2017Review
- Is there evidence for statins in the treatment of aortic valve stenosis?World journal of cardiology · 2017Review
- Response to Statin Use and Aneurysm Risk in Patients With Bicuspid Aortic Valve Disease.Clinical cardiology · 2016Article
- Author's Reply.Clinical cardiology · 2016Article
- A Retrospective Observational Study to Assess Prescription Pattern in Patients with Type B Aortic Dissection and Treatment Outcome.BioMed research international · 2016Observational
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12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNo medical therapy has been proven to prevent the progression of aortic dilatation in bicuspid aortic valve (BAV) disease, and prophylactic aortic surgery remains the mainstay of treatment. HYPOTHESIS: Among patients with BAV disease who are referred for surgery, preoperative statin use is associated with decreased odds of ascending aortic dilatation.
methodsWe reviewed all BAV patients who underwent aortic valve and/or aortic surgery at our center between April 2004 and December 2013. Aortic diameter (AD), defined as the maximum ascending aortic dimension, was determined by magnetic resonance imaging, computed tomography, or echocardiography. Patients were divided into 2 groups: maximal AD <4.5 cm or ≥4.5 cm. The association between preoperative statin use and aortic dilatation was assessed using multivariable logistic regression modeling.
resultsOf 680 consecutive patients, 405 (60%) had AD <4.5 cm (mean age, 60 ± 14 years; 45% on statins), whereas 275 (40%) had AD ≥4.5 cm (mean age, 54 ± 13 years; 35% on statins) at the time of surgery. After adjusting for age, body surface area, sex, hypertension, aortic stenosis, severity of aortic regurgitation, and use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and β-blockers, patients with AD ≥4.5 cm had 0.66× lower odds (95% confidence interval: 0.45-0.96) of being on preoperative statins compared with those with AD <4.5 cm (P = 0.029).
conclusionsIn a retrospective study of BAV patients referred for surgery, preoperative statin use was associated with lower odds of clinically significant ascending aortic dilatation.
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