ArticleBMC molecular biology2015
Conserved and highly expressed tRNA derived fragments in zebrafish.
Article in BMC molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- tRF-1-ArgTCG-1-1 promotes renal fibrosis by regulating β-catenin.Renal failure · 2026Article
- The dynamic interplay between viruses and host non-coding RNA species.FEMS microbiology reviews · 2026Review
- tRNA-derived fragments (tRFs) as key non-coding players in the tumor transcriptome of colorectal cancer: introducing a new suspect responsible for the remaining unknowns of tumor pathology.Medical oncology (Northwood, London, England) · 2025Review
- Article
- An old friend with a new face: tRNA-derived small RNAs with big regulatory potential in cancer biology.British journal of cancer · 2023Review
- The Expression Pattern of tRNA-Derived Small RNAs in AdultInternational journal of molecular sciences · 2023Article
- Review
- Role of tRNA derived fragments in renal ischemia-reperfusion injury.Renal failure · 2022Article
- Testicular miRNAs and tsRNAs provide insight into gene regulation during overwintering and reproduction of Onychostoma macrolepis.Fish physiology and biochemistry · 2022Article
- High Expression of a tRNABiomedicines · 2022Article
- Dicer dependent tRNA derived small RNAs promote nascent RNA silencing.Nucleic acids research · 2022Article
- tRNA derived small RNAs-Small players with big roles.Frontiers in genetics · 2022Review
- 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos.Science advances · 2021Article
- mInternational journal of molecular sciences · 2021Article
- tRFTars: predicting the targets of tRNA-derived fragments.Journal of translational medicine · 2021Article
- Article
- tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immune-activation autism model.RNA biology · 2020Article
- Pathological significance of tRNA-derived small RNAs in neurological disorders.Neural regeneration research · 2020Article
- The role of Transfer RNA-Derived Small RNAs (tsRNAs) in Digestive System Tumors.Journal of Cancer · 2020Review
- Deep sequencing of small non-coding RNA highlights brain-specific expression patterns and RNA cleavage.RNA biology · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall non-coding RNAs (sncRNAs) are a class of transcripts implicated in several eukaryotic regulatory mechanisms, namely gene silencing and chromatin regulation. Despite significant progress in their identification by next generation sequencing (NGS) we are still far from understanding their full diversity and functional repertoire.
resultsHere we report the identification of tRNA derived fragments (tRFs) by NGS of the sncRNA fraction of zebrafish. The tRFs identified are 18-30 nt long, are derived from specific 5' and 3' processing of mature tRNAs and are differentially expressed during development and in differentiated tissues, suggesting that they are likely produced by specific processing rather than random degradation of tRNAs. We further show that a highly expressed tRF (5'tRF-Pro(CGG)) is cleaved in vitro by Dicer and has silencing ability, indicating that it can enter the RNAi pathway. A computational analysis of zebrafish tRFs shows that they are conserved among vertebrates and mining of publicly available datasets reveals that some 5'tRFs are differentially expressed in disease conditions, namely during infection and colorectal cancer.
conclusionstRFs constitute a class of conserved regulatory RNAs in vertebrates and may be involved in mechanisms of genome regulation and in some diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.