Evidence map›Paper›PMID 26694754›Full record

ArticleMolecular cancer2015

BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia.

Norma I Rodríguez-Malavé, Thilini R Fernando, Parth C Patel, Jorge R Contreras, Jayanth Kumar Palanichamy, Tiffany M Tran, Jaime Anguiano, Michael J Davoren, Michael O Alberti, Kimanh T Pioli and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  9. Article
  10. Underexpression ofFrontiers in oncology · 2022
    Article
  11. Article
  12. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2021
    Review
  13. The Role ofCancers · 2020
    Review
  14. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Norma I Rodríguez-MalavéDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. nirodriguez@mednet.ucla.edu.
Thilini R FernandoDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. trfernando@mednet.ucla.edu.
Parth C PatelDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. pcpatel@mednet.ucla.edu.
Jorge R ContrerasDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. jrcontreras@mednet.ucla.edu.
Jayanth Kumar PalanichamyDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. drjayanth@aiims.edu.
Tiffany M TranDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. ttran@mednet.ucla.edu.
Jaime AnguianoDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. janguiano@mednet.ucla.edu.
Michael J DavorenDepartment of Environmental Health Sciences, UCLA, Los Angeles, USA. mdavoren@g.ucla.edu.
Michael O AlbertiDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. malberti@mednet.ucla.edu.
Kimanh T PioliDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. kpioli@mednet.ucla.edu.
Salemiz SandovalDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. salemizsandoval@mednet.ucla.edu.
Gay M CrooksDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. gcrooks@mednet.ucla.edu.
Dinesh S RaoDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. drao@mednet.ucla.edu.
University of California, Los Angeles · USUCLA Health · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Transduction of Human Stem and Progenitor CellsP01HL073104 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHN, DONALD B · 2003 to 2013
$18.3M
TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
UCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3M
Training in Developmental HematologyT32HL086345 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHN, DONALD B · 2007 to 2022
$3.8M
Role of B-cell oncogenes and microRNA-34 in B-lymphopoiesis and neoplasiaK08CA133521 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAO, DINESH S · 2009 to 2013
$784k
NCI NIH HHS CA-16042NCI NIH HHS K08 CA133521NCI NIH HHS K08CA133521NCI NIH HHS NIH T32CA009120NCI NIH HHS P30 CA016042NCI NIH HHS T32 CA009056NCI NIH HHS T32 CA009120NHLBI NIH HHS NIH P01 HL073104NHLBI NIH HHS NIH T32 HL086345NHLBI NIH HHS P01 HL073104NHLBI NIH HHS T32 HL086345NIAID NIH HHS AI-28697NIAID NIH HHS P30 AI028697PHS HHS NIH T32009056
6 · The paper itself

Abstract

backgroundA new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), has been recently described. These lncRNAs are implicated to play pivotal roles in various molecular processes, including development and oncogenesis. Gene expression profiling of human B-ALL samples showed differential lncRNA expression in samples with particular cytogenetic abnormalities. One of the most promising lncRNAs identified, designated B-ALL associated long RNA-6 (BALR-6), had the highest expression in patient samples carrying the MLL rearrangement, and is the focus of this study.

resultsHere, we performed a series of experiments to define the function of BALR-6, including several novel splice forms that we identified. Functionally, siRNA-mediated knockdown of BALR-6 in human B-ALL cell lines caused reduced cell proliferation and increased cell death. Conversely, overexpression of BALR-6 isoforms in both human and mouse cell lines caused increased proliferation and decreased apoptosis. Overexpression of BALR-6 in murine bone marrow transplantation experiments caused a significant increase in early hematopoietic progenitor populations, suggesting that its dysregulation may cause developmental changes. Notably, the knockdown of BALR-6 resulted in global dysregulation of gene expression. The gene set was enriched for leukemia-associated genes, as well as for the transcriptome regulated by Specificity Protein 1 (SP1). We confirmed changes in the expression of SP1, as well as its known interactor and downstream target CREB1. Luciferase reporter assays demonstrated an enhancement of SP1-mediated transcription in the presence of BALR-6. These data provide a putative mechanism for regulation by BALR-6 in B-ALL.

conclusionsOur findings support a role for the novel lncRNA BALR-6 in promoting cell survival in B-ALL. Furthermore, this lncRNA influences gene expression in B-ALL in a manner consistent with a function in transcriptional regulation. Specifically, our findings suggest that BALR-6 expression regulates the transcriptome downstream of SP1, and that this may underlie the function of BALR-6 in B-ALL.

Indexed as

AnimalsCell Line, TumorCell ProliferationCell SurvivalGene Knockdown TechniquesHematopoietic Stem CellsHumansMicePrecursor B-Cell Lymphoblastic Leukemia-LymphomaRNA, Long NoncodingSp1 Transcription FactorTranscriptomeBALR-6 non-coding RNA, humanRNA, Long NoncodingSp1 Transcription Factor

Identifiers

PMID26694754
PMCPMC4688921
OpenAlexW2203305182

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.