Evidence map›Paper›PMID 26694723›Full record

ReviewCurrent cardiology reports2016

Coronary Microvascular Dysfunction, Microvascular Angina, and Management.

Adrián I Löffler, Jamieson M Bourque

Open access · greenAbstract readReview
In one paragraph

Review in Current cardiology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Guideline for Chronic Coronary Syndrome - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Cardio-oncology for Pediatric and Adolescent/Young Adult Patients.Current treatment options in oncology · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Can myocardial perfusion imaging predict outcome in patients with angina and ischemia but no obstructive coronary artery disease (INOCA)?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adrián I LöfflerDivision of Cardiovascular Medicine, University of Virginia Health System, PO Box 800662, Charlottesville, VA, 22908, USA. al2ys@hscmail.mcc.virginia.edu.
Jamieson M BourqueDivision of Cardiovascular Medicine and Radiology, University of Virginia Health System, 1215 Lee Street, Box 800158, Charlottesville, VA, 22908, USA. jbourque@virginia.edu.
University of Virginia Health System · US

Funding

Assessment of Perfusion Reserve and Effects of Exercise in Microvascular AnginaK23HL119620 · NHLBI · UNIVERSITY OF VIRGINIA · PI BOURQUE, JAMIESON MACDONALD · 2013 to 2017
$745k
NHLBI NIH HHS 1K23HL119620-01NHLBI NIH HHS K23 HL119620
6 · The paper itself

Abstract

Recent analyses have found that coronary microvascular dysfunction (CMD) portends a poor prognosis in patients with and without obstructive epicardial coronary artery disease (CAD). Chest pain in the absence of epicardial CAD is a common entity. Angina caused by CMD, microvascular angina (MVA), is often indistinguishable from that caused by obstructive epicardial CAD. The recent emergence of noninvasive techniques that can identify CMD, such as stress positron-emission tomography (PET) and cardiovascular magnetic resonance (CMR) myocardial perfusion imaging, allow improved identification of MVA. Using these tools, higher risk patients with MVA can be differentiated from those at lower risk in the heterogeneous population historically labeled as cardiac syndrome X. Likewise, MVA can be diagnosed in those with obstructive epicardial CAD who have persistent angina despite successful revascularization. There is little evidence to support current treatment strategies for MVA and current literature has not clearly defined CMD or whether therapy improves prognosis.

Indexed as

Coronary AngiographyMyocardial RevascularizationAngiotensin-Converting Enzyme InhibitorsChest PainCoronary Artery DiseaseCoronary CirculationHumansMicrovascular AnginaMyocardial Perfusion ImagingPositron-Emission TomographyPractice Guidelines as TopicPrognosisRegional Blood FlowAngiotensin-Converting Enzyme InhibitorsCoronary microvascular dysfunctionMicrovascular anginaPrognosisTherapeutics

Identifiers

PMID26694723
PMCPMC4835180
OpenAlexW2328529754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.