ReviewBiomedical materials (Bristol, England)2015
Surface biology of collagen scaffold explains blocking of wound contraction and regeneration of skin and peripheral nerves.
Review in Biomedical materials (Bristol, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Dorsal inlay lingual mucosa graft urethroplasty with artificial dermis donor repair for female urethral stricture.World journal of urology · 2026Article
- Marine Collagen-Based Bioink for 3D Bioprinting of a Bilayered Skin Model.Pharmaceutics · 2023Article
- Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects.Scientific reports · 2022Article
- Pitfalls and promises of bile duct alternatives: A narrative review.World journal of gastroenterology · 2022Review
- Skin substitutes with noncultured autologous skin cell suspension heal porcine full-thickness wounds in a one-stage procedure.International wound journal · 2022Article
- Acellular Dermal Matrix Used in Diabetic Foot Ulcers: Clinical Outcomes Supported by Biochemical and Histological Analyses.International journal of molecular sciences · 2021Article
- Healing and Angiogenic Properties of Collagen/Chitosan Scaffolds Enriched with Hyperstable FGF2-STABBiomedicines · 2021Article
- Three-dimensional characterization of collagen remodeling in cell-seeded collagen scaffolds via polarization second harmonic generation.Biomedical optics express · 2021Article
- Reply to: Observation on the article "Long-term follow-up comparison of two different bilayer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings".International wound journal · 2020Article
- Long-term follow-up comparison of two different bi-layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings.International wound journal · 2020Article
- Transcriptomic analysis reveals dynamic molecular changes in skin induced by mechanical forces secondary to tissue expansion.Scientific reports · 2020Article
- Comprehensive Review of Hybrid Collagen and Silk Fibroin for Cutaneous Wound Healing.Materials (Basel, Switzerland) · 2020Review
- Design and biofabrication of dermal regeneration scaffolds: role of oligomeric collagen fibril density and architecture.Regenerative medicine · 2020Article
- The Role of Adipose-Derived Stem Cells, Dermal Regenerative Templates, and Platelet-Rich Plasma in Tissue Engineering-Based Treatments of Chronic Skin Wounds.Stem cells international · 2020Review
- Review
- Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales.Current opinion in biomedical engineering · 2018Article
- Advances in keratinocyte delivery in burn wound care.Advanced drug delivery reviews · 2018Review
- Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We review the details of preparation and of the recently elucidated mechanism of biological (regenerative) activity of a collagen scaffold (dermis regeneration template, DRT) that has induced regeneration of skin and peripheral nerves (PN) in a variety of animal models and in the clinic. DRT is a 3D protein network with optimized pore size in the range 20-125 µm, degradation half-life 14 ± 7 d and ligand densities that exceed 200 µM α1β1 or α2β1 ligands. The pore has been optimized to allow migration of contractile cells (myofibroblasts, MFB) into the scaffold and to provide sufficient specific surface for cell-scaffold interaction; the degradation half-life provides the required time window for satisfactory binding interaction of MFB with the scaffold surface; and the ligand density supplies the appropriate ligands for specific binding of MFB on the scaffold surface. A dramatic change in MFB phenotype takes place following MFB-scaffold binding which has been shown to result in blocking of wound contraction. In both skin wounds and PN wounds the evidence has shown clearly that contraction blocking by DRT is followed by induction of regeneration of nearly perfect organs. The biologically active structure of DRT is required for contraction blocking; well-matched collagen scaffold controls of DRT, with structures that varied from that of DRT, have failed to induce regeneration. Careful processing of collagen scaffolds is required for adequate biological activity of the scaffold surface. The newly understood mechanism provides a relatively complete paradigm of regenerative medicine that can be used to prepare scaffolds that may induce regeneration of other organs in future studies.
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Registered trials
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