ArticleObesity (Silver Spring, Md.)2016
Adipose tissue attenuation as a marker of adipose tissue quality: Associations with six-year changes in body weight.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Antiretroviral Therapy Initiation Is Associated With Decreased Visceral and Subcutaneous Adipose Tissue Density in People Living With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Visceral and subcutaneous fat attenuation as prognostic indicators of survival in castration resistant prostate cancer.Prostate international · 2026Article
- MCAUnet: a deep learning framework for automated quantification of body composition in liver cirrhosis patients.BMC medical imaging · 2025Article
- Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity.Insights into imaging · 2021Article
- CoreSlicer: a web toolkit for analytic morphomics.BMC medical imaging · 2019Article
- Associations of cardiovascular fat radiodensity and vascular calcification in midlife women: The SWAN cardiovascular fat ancillary study.Atherosclerosis · 2018Article
- Influence of Contrast Administration on Computed Tomography-Based Analysis of Visceral Adipose and Skeletal Muscle Tissue in Clear Cell Renal Cell Carcinoma.JPEN. Journal of parenteral and enteral nutrition · 2018Article
- Association of proton density fat fraction in adipose tissue with imaging-based and anthropometric obesity markers in adults.International journal of obesity (2005) · 2018Article
- Association of Changes in Abdominal Fat Quantity and Quality With Incident Cardiovascular Disease Risk Factors.Journal of the American College of Cardiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveWeight gain is associated with fat volume increases, but associations with fat quality are less well characterized The associations of weight change with visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volume and attenuation were investigated.
methodsComputed tomography abdominal scans were acquired on a Framingham Heart Study subset (N = 836; 40.2% women; mean age 45.7 years), a mean of 6.1 years apart. Fat attenuation estimated fat quality.
resultsMean weight change was +2.0 (SD 6.8; IQR -0.7, 5.0) kg in women and +2.7 (SD 6.0; IQR -0.5, 5.4) kg in men. Per 2.5 kg weight increase in women, VAT volume increased 126 cm(3) (95% CI, 112-140, p < 0.0001), SAT volume increased 258 cm(3) (95% CI, 239-278, p < 0.0001), and fat attenuation decreased (i.e., fat quality worsened) in VAT and SAT (p < 0.0001). Increasing VAT volume was associated with decreasing fat attenuation even after accounting for weight change. Relative to weight-stable women (n = 129), women who lost >2.5 kg (n = 58) had smaller SAT attenuation decreases (p < 0.0001). Similar patterns were seen in men.
conclusionsWeight gain was associated with decreases in fat attenuation independent of VAT and SAT volume changes. These findings highlighted the associations of weight gain and worsening fat attenuation, suggesting fat attenuation may be dynamic.
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Registered trials
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