Evidence map›Paper›PMID 26694596›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Supplementation with omega-3 fish oil has no effect on bone mineral density in adults with knee osteoarthritis: a 2-year randomized controlled trial.

J S Chen, C L Hill, S Lester, C D Ruediger, R Battersby, G Jones, L G Cleland, L M March

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 7 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 7 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. The Effects ofNutrients · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

J S ChenThe University of Sydney Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, NSW, 2065, Australia.
C L HillDiscipline of Medicine, The University of Adelaide, Adelaide, Australia. Catherine.Hill@health.sa.gov.au.ORCID http://orcid.org/0000-0001-8289-4922
S LesterRheum Unit, The Queen Elizabeth Hospital, Woodville, Australia.
C D RuedigerDiscipline of Medicine, The University of Adelaide, Adelaide, Australia.
R BattersbyDiscipline of Surgery, The University of Adelaide, Adelaide, Australia.
G JonesMenzies Research Institute, Hobart, Australia.
L G ClelandRoyal Adelaide Hospital, Adelaide, Australia.
L M MarchThe University of Sydney Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, NSW, 2065, Australia.
The University of Adelaide · AUThe University of Sydney · AUMenzies School of Health Research · AUQueen Elizabeth Hospital · AURoyal Adelaide Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThis study aimed to determine the effect of fish oil on bone mineral density (BMD). There were no differences in the 2-year BMD measures between high and low dose groups after adjusting for baseline BMD. This randomized controlled trial did not demonstrate any efficacy of omega-3 fatty acids on bone loss in adults.

introductionThe purpose of this study is to investigate whether supplementation with high dose omega-3 fish oil could have an impact on BMD.

methodsIn a multicentre, double-blind randomized controlled trial (RCT) (ACTRN 12607000415404), 202 Australian participants aged ≥40 with knee osteoarthritis (mean age, 61.0 ± 10.0 years; 49 % female) were randomized to receive either high dose (4.5 g eicosapentaenoic acid and docosahexaenoic acid daily) or low dose (0.45 g/day) omega-3 fish oil for 2 years. BMD was assessed at baseline and 2 years by dual energy X-ray absorptiometry.

resultsIn subjects with baseline and 2-year assessments, mean standardized BMD at baseline for low or high dose group was 1198 ± 198 and 1157 ± 169 mg/cm(2), respectively, for the lumbar spine and was 1035 ± 165 and 1017 ± 174 mg/cm(2), respectively, for the femoral neck. There were no differences in the 2-year BMD measures between high and low dose groups after adjusting for baseline BMD in the complete case regression analyses (lumbar spine 3.7, 95 % confidence interval (CI) -7.9 to 15.3 mg/cm(2) and femoral neck -5.5, 95 % CI -14.9 to 3.9 mg/cm(2)). The findings did not change with additional adjustments of age, gender, study centre and uses of bone-related drugs during the study period as well as using the intention-to-treat analysis or limiting to older participants (≥55 years at the baseline) (all P ≥ 0.25). Mild adverse events such as headache and gastrointestinal intolerance were common but did not occur more frequently in either group. There were no serious adverse events related to the intervention.

conclusionA 2-year supplementation with high-dose omega-3 fish oil did not alter bone loss among men and women with knee osteoarthritis.

Indexed as

Dietary SupplementsAbsorptiometry, PhotonAdultAgedAged, 80 and overBone DensityDose-Response Relationship, DrugDouble-Blind MethodFatty Acids, Omega-3FemaleFemur NeckHumansLumbar VertebraeMaleMiddle AgedOsteoarthritis, KneeFatty Acids, Omega-3Bone mineral densityDocosahexaenoic acidEicosapentaenoic acidOmega-3 fatty acidsRandomized controlled trial

Identifiers

PMID26694596
OpenAlexW2199181007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.