ArticleNanoscale2016
Calcinated gold nanoparticle arrays for on-chip, multiplexed and matrix-free mass spectrometric analysis of peptides and small molecules.
Article in Nanoscale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Efficient Analysis of Small Molecules via Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (LDI-TOF MS) Using Gold Nanoshells with Nanogaps.Nanomaterials (Basel, Switzerland) · 2023Article
- Surface Plasmon Resonance: Material and Interface Design for Universal Accessibility.Analytical chemistry · 2018Review
- Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules.Nanomaterials (Basel, Switzerland) · 2017Review
- Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review.Nanomaterials (Basel, Switzerland) · 2017Review
- Satellite-like Gold Nanocomposites for Targeted Mass Spectrometry Imaging of Tumor Tissues.Nanotheranostics · 2017Article
- Plasmonic nanodisc arrays on calcinated titania for multimodal analysis of phosphorylated peptides.RSC advances · 2017Article
- Bioinspired Assemblies and Plasmonic Interfaces for Electrochemical Biosensing.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A patterned gold nanoparticle microarray, functionalized with a nanoscale silicate coating, has been developed for on-chip, high-throughput mass spectrometric analyses of biomolecules with minimal sample preparation and reagent costs. Fabrication was realized by the combination of layer-by-layer functionalization of the nanoparticles with suitable polyelectrolytes, followed by fluidic patterning of the glass microarray support and calcination for permanent fixation of the nano-coating. Performance of the microarray was evaluated for surface-assisted laser-desorption/ionization mass spectrometry (SALDI-MS), where the nano-silicate coating was found to enhance SALDI efficiency, resulting in comparable performance to some common organic matrices for small and medium sized molecules. Performance contributing factors of this material have been discussed; heat confinement and interband transition/plasmonic resonance may play important roles. Taking the accessibility of fabrication, performance, and reusability of this substrate together, the material developed here provides a new tool for multiplexed and chip-based mass spectrometric analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.