ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2016
Novel human intervertebral disc strain template to quantify regional three-dimensional strains in a population and compare to internal strains predicted by a finite element model.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration.JOR spine · 2026Article
- Degeneration-Driven and Load-Modulated Fluid-Driven Viscoelasticity of the Human Intervertebral Disc: A Probabilistic Biphasic Swelling Modeling Study.Bioengineering (Basel, Switzerland) · 2026Article
- Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Review
- Article
- TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc.JOR spine · 2023Article
- Off-Axis Loading Fixture for Spine Biomechanics: Combined Compression and Bending.Journal of biomechanical engineering · 2023Article
- MRI-based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading.JOR spine · 2023Article
- Design of a flexing organ-chip to modelBiomicrofluidics · 2022Article
- Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain.JOR spine · 2021Article
- Intervertebral Disc-on-a-Chip as AdvancedFrontiers in bioengineering and biotechnology · 2021Review
- Sensitivity of Intervertebral Disc Finite Element Models to Internal Geometric and Non-geometric Parameters.Frontiers in bioengineering and biotechnology · 2021Article
- Experimental and Computational Comparison of Intervertebral Disc Bulge for Specimen-Specific Model Evaluation Based on Imaging.Frontiers in bioengineering and biotechnology · 2021Article
- The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI.Frontiers in bioengineering and biotechnology · 2020Article
- Rapid determination of internal strains in soft tissues using an experimentally calibrated finite element model derived from magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2020Article
- A comparison of stress in cracked fibrous tissue specimens with varied crack location, loading, and orientation using finite element analysis.Journal of the mechanical behavior of biomedical materials · 2016Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Tissue strain is an important indicator of mechanical function, but is difficult to noninvasively measure in the intervertebral disc. The objective of this study was to generate a disc strain template, a 3D average of disc strain, of a group of human L4-L5 discs loaded in axial compression. To do so, magnetic resonance images of uncompressed discs were used to create an average disc shape. Next, the strain tensors were calculated pixel-wise by using a previously developed registration algorithm. Individual disc strain tensor components were then transformed to the template space and averaged to create the disc strain template. The strain template reduced individual variability while highlighting group trends. For example, higher axial and circumferential strains were present in the lateral and posterolateral regions of the disc, which may lead to annular tears. This quantification of group-level trends in local 3D strain is a significant step forward in the study of disc biomechanics. These trends were compared to a finite element model that had been previously validated against the disc-level mechanical response. Depending on the strain component, 81-99% of the regions within the finite element model had calculated strains within one standard deviation of the template strain results. The template creation technique provides a new measurement technique useful for a wide range of studies, including more complex loading conditions, the effect of disc pathologies and degeneration, damage mechanisms, and design and evaluation of treatments. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1264-1273, 2016.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.