Evidence map›Paper›PMID 26694509›Full record

ReviewWormBook : the online review of C. elegans biology2017

Meiosis.

Kenneth J Hillers, Verena Jantsch, Enrique Martinez-Perez, Judith L Yanowitz

Open access · diamondAbstract readReview
In one paragraph

Review in WormBook : the online review of C. elegans biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 122 citations in OpenAlex.

  1. Article
  2. Review
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Expanding thebioRxiv : the preprint server for biology · 2026
    Article
  5. Active maintenance of meiosis-specific chromosome structures inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Active maintenance of meiosis-specific chromosome structures inbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kenneth J HillersBiological Sciences Department, California Polytechnic State University, San Luis Obispo, CA 93407, United States.
Verena JantschDepartment of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter,1030 Vienna, Austria.
Enrique Martinez-PerezMRC Clinical Sciences Centre, Imperial College, London W12 0NN, United Kingdom.
Judith L YanowitzMagee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
California Polytechnic State University · US

Funding

Undergraduate Summer Research Supplement for 5R01GM104007-07: Characterization of a Meiotic Crossover Surveillance SystemR01GM104007 · NIGMS · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI YANOWITZ, JUDITH L · 2013 to 2021
$2.6M
COELOMOCYTES IN C.ELEGANS--CELL FATE DETERMINATIONF32HD008715 · NICHD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI YANOWITZ, JUDITH L · 2000 to 2002
$112k
Medical Research Council MC_U120097113NICHD NIH HHS F32 HD008715NIGMS NIH HHS R01 GM104007
6 · The paper itself

Abstract

Sexual reproduction requires the production of haploid gametes (sperm and egg) with only one copy of each chromosome; fertilization then restores the diploid chromosome content in the next generation. This reduction in genetic content is accomplished during a specialized cell division called meiosis, in which two rounds of chromosome segregation follow a single round of DNA replication. In preparation for the first meiotic division, homologous chromosomes pair and synapse, creating a context that promotes formation of crossover recombination events. These crossovers, in conjunction with sister chromatid cohesion, serve to connect the two homologs and facilitate their segregation to opposite poles during the first meiotic division. During the second meiotic division, which is similar to mitosis, sister chromatids separate; the resultant products are haploid cells that become gametes. In Caenorhabditis elegans (and most other eukaryotes) homologous pairing and recombination are required for proper chromosome inheritance during meiosis; accordingly, the events of meiosis are tightly coordinated to ensure the proper execution of these events. In this chapter, we review the seminal events of meiosis: pairing of homologous chromosomes, the changes in chromosome structure that chromosomes undergo during meiosis, the events of meiotic recombination, the differentiation of homologous chromosome pairs into structures optimized for proper chromosome segregation at Meiosis I, and the ultimate segregation of chromosomes during the meiotic divisions. We also review the regulatory processes that ensure the coordinated execution of these meiotic events during prophase I.

Indexed as

MeiosisAnimalsCaenorhabditis elegansCell DivisionChromosomesChromosome SegregationMeiotic Prophase IRecombination, Genetic

Identifiers

PMID26694509
PMCPMC5215044
OpenAlexW4240096500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.