ArticleNutrients2015
Anti-Obesity Effect of 6,8-Diprenylgenistein, an Isoflavonoid of Cudrania tricuspidata Fruits in High-Fat Diet-Induced Obese Mice.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- The Growth Characteristics and the Active Compounds ofPlants (Basel, Switzerland) · 2023Article
- Effects of Genistein on Lipid Metabolism, Antioxidant Activity, and Immunity of Common Carp (Aquaculture nutrition · 2023Article
- Antibacterial Activities of Prenylated Isoflavones fromMolecules (Basel, Switzerland) · 2021Article
- Intraperitoneal injection of genistein affects the distribution and metabolism of cholesterol in female yellow catfish Tachysurus fulvidraco.Fish physiology and biochemistry · 2021Article
- Protective Effect ofMolecules (Basel, Switzerland) · 2021Article
- Effects of 6,8-Diprenylgenistein on VEGF-A-Induced Lymphangiogenesis and Lymph Node Metastasis in an Oral Cancer Sentinel Lymph Node Animal Model.International journal of molecular sciences · 2021Article
- Article
- Cudrania tricuspidata Root Extract Prevents Methylglyoxal-Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells.Oxidative medicine and cellular longevity · 2021Article
- Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.Scientific reports · 2020Article
- Role of Flavonoids in The Interactions among Obesity, Inflammation, and Autophagy.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Review
- Synergistic effect of Lactobacillus gasseri and Cudrania tricuspidata on the modulation of body weight and gut microbiota structure in diet-induced obese mice.Applied microbiology and biotechnology · 2020Article
- Gastroprotective Effects ofPreventive nutrition and food science · 2020Article
- Tyrosinase Inhibition Antioxidant Effect and Cytotoxicity Studies of the Extracts of Cudrania tricuspidata Fruit Standardized in Chlorogenic Acid.Molecules (Basel, Switzerland) · 2019Article
- Ethanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Changes in Plasma Metabolites Concentrations in Obese Dogs Supplemented With Anti-oxidant Compound.Frontiers in nutrition · 2018Article
- Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts.Molecules (Basel, Switzerland) · 2017Article
- Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome.International journal of molecular sciences · 2017Article
- Article
- Comparison of pancreatic lipase inhibitory isoflavonoids from unripe and ripe fruits of Cudrania tricuspidata.PloS one · 2017Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity, which is characterized by excessive fat accumulation, is associated with several pathological disorders, including metabolic diseases. In this study, the anti-obesity effect of 6,8-diprenylgenistein (DPG), a major isoflavonoid of Cudrania tricuspidata fruits was investigated using high fat-diet (HFD)-induced obese mice at the doses of 10 and 30 mg/kg for six week. The body weight of the DPG-treated groups was significantly lower compared to the HFD-treated group. In addition, fat accumulation in epididymal adipose tissue and liver was dramatically decreased in the HFD + DPG groups. The food efficiency ratios of the HFD + DPG groups were also lower compared to the HFD group with the same food intake. Metabolic parameters that had increased in the HFD group were decreased in the HFD + DPG groups. Further studies demonstrate that DPG efficiently reduces lipogenic genes by regulation of transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), and hormones, such as leptin and adiponection. DPG also regulates acetyl-CoA carboxylase (ACC) and hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) by AMP-activated protein kinase (AMPK) activation. Taken together, DPG is beneficial for the regulation of obesity, especially resulting from high fat intake.
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