Evidence map›Paper›PMID 26693964›Full record

Trial reportEpilepsia2016

A pilot randomized controlled clinical trial to improve antiepileptic drug adherence in young children with epilepsy.

Avani C Modi, Shanna M Guilfoyle, Krista A Mann, Joseph R Rausch

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Epilepsia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 7 pooled it
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Care delivery and self-management strategies for children with epilepsy.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Care delivery and self-management strategies for children with epilepsy.The Cochrane database of systematic reviews · 2018
    Pooled it
  6. Psychological treatments for people with epilepsy.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Interventions to Promote Oral Medication Adherence in the Pediatric Chronic Illness Population: A Systematic Review From the Children's Oncology Group.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
    Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Sudden Unexpected Death in Epilepsy (SUDEP): A Review of Risk Factors and Possible Interventions in Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021
    Review
  19. Psychological treatments for people with epilepsy.The Cochrane database of systematic reviews · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Avani C ModiDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.
Shanna M GuilfoyleDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.
Krista A MannDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.
Joseph R RauschDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.
Cincinnati Children's Hospital Medical Center · US

Funding

Novel Adherence Measurement and Intervention in Children with New-Onset EpilepsyK23HD057333 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI MODI, AVANI C · 2008 to 2012
$634k
NICHD NIH HHS K23 HD057333NICHD NIH HHS K23HD057333
6 · The paper itself

Abstract

The primary aim was to examine the preliminary efficacy of a family tailored problem-solving intervention to improve antiepileptic drug (AED) adherence in families of children with new-onset epilepsy. Secondary aims were to assess changes in targeted mechanisms and treatment feasibility and acceptability. Fifty families (M(age) = 7.6 ± 3.0; 80% Caucasian; 42% idiopathic localization related) completed baseline questionnaires and were given an electronic monitor to observe daily AED adherence. If adherence was ≤ 95% in the first 7 months of the study, families were randomized (Supporting Treatment Adherence Regimens (STAR): n = 11; Treatment as Usual (TAU): n = 12). Twenty-one families were not randomized due to adherence being ≥95%. The STAR intervention included four face-to-face and two telephone problem-solving sessions over 8 weeks. Significant group differences in adherence were found during active intervention (weeks 4-6; TAU = -12.0 vs. STAR = 18.1, p < 0.01; and weeks session 6-8: TAU = -9.7 vs. STAR = 15.3, p < 0.05). Children who received the STAR intervention exhibited improved adherence compared to children in the TAU group during active treatment. Significant changes in epilepsy knowledge and management were noted for the STAR group. Families expressed benefitting from the STAR intervention. Future studies should include a larger sample size and booster intervention sessions to maintain treatment effects over time.

Indexed as

AnticonvulsantsChildChild, PreschoolEpilepsyFamilyFemaleFollow-Up StudiesHumansMaleMedication AdherencePilot ProjectsSurveys and QuestionnairesAnticonvulsantsComplianceInterventionPediatric epilepsyProblem solvingSelf-management

Identifiers

PMID26693964
PMCPMC4783218
OpenAlexW2205130063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.