ArticleArchives of osteoporosis2016
Accumulation of risk factors associated with poor bone health in older adults.
Article in Archives of osteoporosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- The relationship of physical activity and sedentary behavior patterns with osteoporosis in older women: a dose-response analysis.Frontiers in public health · 2026Article
- 60 is the new 40: preparing for better bone health in later life.Frontiers in aging · 2025Article
- Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Risk Factors for Falls and Fall-Related Fractures in Community-Living Older People with Pain: A Prospective Cohort Study.International journal of environmental research and public health · 2023Article
- The Early Detection of Osteoporosis in a Cohort of Healthcare Workers: Is There Room for a Screening Program?International journal of environmental research and public health · 2021Article
- Interaction of Nutrition and Exercise on Bone and Muscle.European endocrinology · 2019Article
- The Hertfordshire Cohort Study: an overview.F1000Research · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
unlabelledClustering of factors linked with poor bone health is common in older adults and is associated with lower bone density and increased fracture risk in women. PURPOSE: Many factors are associated with bone mineral density, which in turn is strongly linked with risk of fragility fracture. We assessed how commonly clustering of risk factors occurs and related such clustering to bone mineral density in a population of older community-dwelling men and women.
methodThis is a cross-sectional study with 498 men and 498 women aged 59 to 72 years, who were participants in the Hertfordshire Cohort Study, in whom incident fracture was recorded. Physical activity, diet quality, history of prior fracture, family history of fracture, cigarette and alcohol consumption and comorbidities were obtained through baseline questionnaire. Measurements of grip strength and bone mineral density of the lumbar spine and total femur were also taken.
resultsClustering of risk factors was common, with over 30% having two or more. In women, a graded association between the number of risk factors and low bone density was seen, and strong relationships were also seen between the number of risk factors and incident fracture; women with three or more risk factors had an adjusted hazard ratio (HR) of incident fracture of 5.98 (1.67, 21.43; p = 0.006) compared to women with no risk factors; women with two risk factors had an adjusted HR of 2.97 (1.14, 7.74; p = 0.03) and those with one, 2.28 (0.90, 5.75; p = 0.08).
conclusionClustering of risk factors for poor bone health is common in community-dwelling older adults and is associated with increased risk of fracture and adverse bone health in women.
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