Evidence map›Paper›PMID 26693909›Full record

SynthesisPloS one2015

Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review.

Caroline Moura Martins Lobo Santos, Ronaldo Lira-Junior, Ricardo Guimarães Fischer, Ana Paula Pires Santos, Branca Heloisa Oliveira

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Antibiotics in periodontal treatment: an umbrella review.Frontiers in cellular and infection microbiology · 2025
    Pooled it
  4. Pooled it
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  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Review
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  14. Article
  15. More than just teeth: How oral health can affect the heart.American heart journal plus : cardiology research and practice · 2024
    Review
  16. Article
  17. Review
  18. A novel lncRNA-mediated epigenetic regulatory mechanism in periodontitis.International journal of biological sciences · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Caroline Moura Martins Lobo SantosDepartment of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Ronaldo Lira-JuniorDepartment of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Ricardo Guimarães FischerDepartment of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Ana Paula Pires SantosDepartment of Community and Preventive Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Branca Heloisa OliveiraDepartment of Community and Preventive Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients. MATERIALS AND

methodsTwo independent reviewers screened for controlled clinical trials with at least 6-month follow-up in six electronic databases, registers of clinical trials, meeting abstracts and four major dental journals. After duplicates removal, electronic and hand searches yielded 1,878 records; 18 full-text articles were independently read by two reviewers. To evaluate the additional effect of antibiotic usage, pooled weighted mean differences and 95% confidence intervals were calculated using a fixed effects model.

resultsFive studies met the inclusion criteria, four of which were included in meta-analyses. The meta-analyses showed a significant effect favouring SRP plus antibiotic for reductions in mean probing depth (PD) (-0.22 mm [-0.34, -0.11]) and mean percentage of bleeding on probing (BoP) (4% [-7, -1]). There was no significant effect for clinical attachment level gain and plaque index reduction. No study reported on tooth loss and oral health-related quality of life.

conclusionAdjunctive systemic antibiotic use in diabetic patients provides a small additional benefit in terms of reductions in mean PD and mean percentage of BoP. REGISTRATION: PROSPERO: CRD42013006389.

Indexed as

Anti-Bacterial AgentsClinical Trials as TopicDatabases, FactualDiabetes ComplicationsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansMalePeriodontitisAnti-Bacterial Agents

Identifiers

PMID26693909
PMCPMC4687852

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.