ArticleBMC musculoskeletal disorders2015
Diagnostic utility of joint fluid metal ion measurement for histopathological findings in metal-on-metal hip replacements.
Article in BMC musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Letter to the Editor on "Total Hip Arthroplasty in the Ultrayoung".Arthroplasty today · 2024Article
- Radiation impacts on toxicity of cobalt-chromium (CoCr) implant debris.Nanotoxicology · 2023Article
- Review
- Synovial Fluid Metal Ion Levels are Superior to Blood Metal Ion Levels in Predicting an Adverse Local Tissue Reaction in Failed Total Hip Arthroplasty.The Journal of arthroplasty · 2021Article
- Retention of metals in periprosthetic tissues of patients with metal-on-metal total hip arthroplasty is reflected in the synovial fluid to blood cobalt transfer ratio in the presence of a pseudotumour.BMC musculoskeletal disorders · 2020Article
- N-Acetyl-Cysteine Reduces Blood Chromium and Cobalt Levels in Metal-on-Metal Hip Arthroplasty.Arthroplasty today · 2020Article
- A Mid- to Long-Term Follow-Up Experience with a Specific Metal-on-Metal Total Hip Arthroplasty Design.Joints · 2019Article
- Host-specific factors affect the pathogenesis of adverse reaction to metal debris.BMC musculoskeletal disorders · 2019Article
- Article
- Analysis of bearing wear, whole blood and synovial fluid metal ion concentrations and histopathological findings in patients with failed ASR hip resurfacings.BMC musculoskeletal disorders · 2017Article
- Current Pathologic Scoring Systems for Metal-on-metal THA Revisions are not Reproducible.Clinical orthopaedics and related research · 2017Article
- Metal-on-metal total hip arthroplasty: risk factors for pseudotumours and clinical systematic evaluation.International orthopaedics · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn vivo assessment of inflammatory responses in the synovia of patients with MoM hip replacements would be useful in the determination of the prognosis of the hip replacement. Aims of the study was to investigate the correlation between cobalt and chrome levels in joint fluid with histopathological findings and the predictive ability of metal ion levels for these findings.
methodsIn 163 revision surgeries (141 ASR THAs and 22 ASR hip resurfacings) joint fluid chrome and cobalt levels were assessed and histological analysis of synovial tissues was performed. Histological analysis included assessment of histiocytes, particle load, surface necrosis, lymphocyte cuffs and ALVAL-score.
resultsSurface necrosis correlated positively with cobalt levels both in both groups. Neither chrome nor cobalt level had even fair discriminative ability to predict the presence or severity of any histological finding in the THA group. In the hip resurfacing group, cobalt level had good discriminative ability to predict the presence of perivascular lymphocytes and ALVAL-score of ≥ 7 whereas chrome had good discriminative ability to predict surface necrosis, metal particle load and ALVAL-score of ≥ 7.
conclusionsMeasurement of metal ion levels following joint fluid aspirate offers no relevant information with regard to histopathological findings in patients with large-diameter MoM THAs. Limited information may be gained from assessment of joint fluid metal ion levels in patients with hip resurfacings, but disadvantages of an aspirate must be carefully reviewed.
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