Evidence map›Paper›PMID 26693477›Full record

SynthesisBioMed research international2015

Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review.

Alexandra Martini de Oliveira, Marcia Radanovic, Patrícia Cotting Homem de Mello, Patrícia Cardoso Buchain, Adriana Dias Barbosa Vizzotto, Diego L Celestino, Florindo Stella, Catherine V Piersol, Orestes V Forlenza

2 registry-linked trialsOpen access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 9 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03451760 phase2unknown statusnot on this mapstarted 2018, after this paper: background citation

Feru-guard (Ferulic Acid and Angelica Archangelica Extract) for Behavioral Symptoms in Dementia

TypeinterventionalSponsorGlovia Co., Ltd.Ran2018 to 2019Enrolled70ConditionsBehavioral and Psychiatric Symptoms of DementiaArmsFeru-guard 100M, Feru-guard 100M Placebo
NCT03662360 nacompletednot on this mapstarted 2018, after this paper: background citation

Elderly Patients With Dementia in the Department of Acute Geriatrics: Pilot Study, Monocentric, Randomized Use of Aromatherapy as a Complementary Treatment to Psychopharmacotherapy in Psychological Disorders and BPSD Behavior

TypeinterventionalSponsorClinica Luganese MoncuccoRan2018 to 2018Enrolled32ConditionsBPSD (Behavioral and Psycological Symptoms of Dementia)Armsessential oils
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 9 syntheses or guidelines pooled it, 248 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Aromatherapy for dementia.The Cochrane database of systematic reviews · 2020
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Hearing Loss Treatment in Older Adults With Cognitive Impairment: A Systematic Review.Journal of speech, language, and hearing research : JSLHR · 2018
    Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Review
  15. Temporal Patterns of BPSD During a Multimodal Non-Pharmacological Intervention in Nursing Home and Daycare Centre Settings.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Loneliness as a Public Health Challenge: A Systematic Review and Meta-Analysis to Inform Policy and Practice.European journal of investigation in health, psychology and education · 2025
    Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alexandra Martini de OliveiraLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil ; Occupational Therapy Service, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil.
Marcia RadanovicLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil.
Patrícia Cotting Homem de MelloLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil ; Occupational Therapy Service, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil.
Patrícia Cardoso BuchainOccupational Therapy Service, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil.
Adriana Dias Barbosa VizzottoOccupational Therapy Service, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil.
Diego L CelestinoLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil.
Florindo StellaBiosciences Institute, Universidade Estadual Paulista (UNESP), 13506-900 Rio Claro, SP, Brazil.
Catherine V PiersolDepartment of Occupational Therapy, Clinical Director, Jefferson Elder Care, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Orestes V ForlenzaLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403-010 São Paulo, SP, Brazil.
Universidade de São Paulo · BRThomas Jefferson University · USUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBehavioral and psychological symptoms of dementia (BPSD) are defined as a group of symptoms of disturbed perceptive thought content, mood, or behavior that include agitation, depression, apathy, repetitive questioning, psychosis, aggression, sleep problems, and wandering. Care of patients with BPSD involves pharmacological and nonpharmacological interventions. We reviewed studies of nonpharmacological interventions published in the last 10 years.

methodsWe performed a systematic review in Medline and Embase databases, in the last 10 years, until June 2015. Key words used were (1) non-pharmacological interventions, (2) behavioral symptoms, (3) psychological symptoms, and (4) dementia.

resultsWe included 20 studies published in this period. Among these studies, program activities were more frequent (five studies) and the symptoms more responsive to the interventions were agitation. DISCUSSION: Studies are heterogeneous in many aspects, including size sample, intervention, and instruments of measures.

conclusionNonpharmacological interventions are able to provide positive results in reducing symptoms of BPSD. Most studies have shown that these interventions have important and significant efficacy.

Indexed as

AggressionDementiaDepressionHumansMusculoskeletal ManipulationsPsychomotor AgitationPsychotic Disorders

Identifiers

PMID26693477
PMCPMC4676992
OpenAlexW2173996012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.