Symptomatic Massive Splenomegaly in Persistent Polyclonal B-cell Lymphocytosis Requiring Splenectomy.

Shanel B Bhagwandin, Elliot S Weisenberg, Howard Ozer, Ajay V Maker

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Article in Open journal of clinical & medical case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 78% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Polyclonal B-cell lymphocytosis in English bulldogs.Journal of veterinary internal medicine · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shanel B BhagwandinDepartment of Surgery, University of Illinois at Chicago Medical Center, Chicago, Illinois.

Elliot S WeisenbergDepartment of Pathology, University of Illinois at Chicago Medical Center, Chicago, Illinois.

Howard OzerSection of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago Medical Center, Chicago, Illinois.

Ajay V MakerDepartment of Surgery, University of Illinois at Chicago Medical Center, Chicago, Illinois.

University of Chicago Medical Center · USUniversity of Illinois Chicago · US

Funding

Enhancing anti-tumor immune responses in colon cancer metastasesK08CA190855 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAKER, AJAY V. · 2014 to 2018

$909k

NCI NIH HHS K08 CA190855

6 · The paper itself

Abstract

introductionPersistent polyclonal B-cell lymphocytosis (PPBL) is a rare lymphoproliferative hematological disease characterized by binucleated lymphocytes, CD 19 CASE PRESENTATION: We present a case of PPBL in a young man with massive splenomegaly that mimicked isolated splenic lymphoma requiring splenectomy for persistent pain, symptoms, and diagnosis. DISCUSSION: Determining the etiology of splenomegaly in these patients is often confounding due to a lack of a tissue diagnosis and the limited morphological and immuno-histochemical features of PPBL, therefore, the presentation remains highly concerning for lymphoma.

conclusionThe presentation, surgical treatment, tissue and peripheral blood molecular analysis, and flow cytometry integral to managing these patients and to prevent an assumptive and misleading diagnosis are reviewed.

Identifiers

PMID26693179

PMCPMC4675630

OpenAlexW2411920615

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.