ArticleTranslational vision science & technology2015
Feasibility of Structural and Functional MRI Acquisition with Unpowered Implants in Argus II Retinal Prosthesis Patients: A Case Study.
Article in Translational vision science & technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Visual cortical thickness increases with prolonged artificial vision restoration.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Pattern-reversal visual evoked potentials in prosthetic vision and simulated visual reduction.BMJ open ophthalmology · 2024Article
- Visual-tactile shape perception in the visually restored with artificial vision.Journal of vision · 2022Article
- Sight restoration reverses blindness-induced cross-modal functional connectivity changes between the visual and somatosensory cortex at rest.Frontiers in neuroscience · 2022Article
- Structural evaluation in inherited retinal diseases.The British journal of ophthalmology · 2021Review
- Multisensory perception in Argus II retinal prosthesis patients: Leveraging auditory-visual mappings to enhance prosthesis outcomes.Vision research · 2021Article
- Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging.Translational vision science & technology · 2019Article
- Now is the Critical Time for Engineered Neuroplasticity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Structure-function correlations in Retinitis Pigmentosa patients with partially preserved vision: a voxel-based morphometry study.Scientific reports · 2017Article
- Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.NeuroImage. Clinical · 2017Article
- Visual Cortex Plasticity Following Peripheral Damage To The Visual System: fMRI Evidence.Current neurology and neuroscience reports · 2016Review
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Authors and funding
7 authors.
Funding
Abstract
purposeMagnetic resonance imaging (MRI) can measure the effects of vision loss and recovery on brain function and structure. In this case study, we sought to determine the feasibility of acquiring anatomical and functional MRI data in recipients of the Argus II epiretinal prosthesis system.
methodsFollowing successful implantation with the Argus II device, two retinitis pigmentosa (RP) patients completed MRI scans with their implant unpowered to measure primary visual cortex (V1) functional responses to a tactile task, whole-brain morphometry, V1 cortical thickness, and diffusion properties of the optic tract and optic radiation. Measurements in the subjects with the Argus II implant were compared to measurements obtained previously from RP patients and sighted individuals.
resultsThe presence of the Argus II implant resulted in artifacts that were localized around the patient's implanted eye and did not extend into cortical regions or white matter tracts associated with the visual system. Structural data on V1 cortical thickness and the retinofugal tract obtained from the two Argus II subjects fell within the ranges of sighted and RP groups. When compared to the RP and sighted subjects, Argus II patients' tactile-evoked cross-modal functional MRI (fMRI) blood oxygen level-dependent (BOLD) responses in V1 also fell within the range of either sighted or RP groups, apparently depending on time since implantation.
conclusionsThis study demonstrates that successful acquisition and quantification of structural and functional MR images are feasible in the presence of the inactive implant and provides preliminary information on functional changes in the brain that may follow sight restoration treatments. TRANSITIONAL RELEVANCE: Successful MRI and fMRI acquisition in Argus II recipients demonstrates feasibility of using MRI to study the effect of retinal prosthesis use on brain structure and function.
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