Evidence map›Paper›PMID 26693020›Full record

ArticleJournal of materials chemistry. B2015

Design of Silk-Vaterite Microsphere Systems as Drug Carriers with pH-responsive Release Behavior.

S S Liu, L J Liu, L Y Xiao, Q Lu, H S Zhu, D L Kaplan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S S LiuNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, People's Republic of China ; College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, People's Republic of China.
L J LiuNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, People's Republic of China ; College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, People's Republic of China.
L Y XiaoNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, People's Republic of China ; College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, People's Republic of China.
Q LuNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, People's Republic of China ; College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, People's Republic of China.
H S ZhuResearch Center of Materials Science, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
D L KaplanNational Engineering Laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, People's Republic of China ; Department of Biomedical Engineering, Tufts University, Medford, MA02155, USA.

Funding

Silica-protein Nanocomposites for Dental RepairR01DE017207 · NIDCR · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2007 to 2016
$3.0M
NIDCR NIH HHS R01 DE017207
6 · The paper itself

Abstract

Improving the therapeutic efficacy of chemotherapy remains a key goal for cancer therapy. Various passive and active targeting strategies have been developed to facilitate drug release targeted to cancer lesions, but actively designing tunable drug release behavior for these needs remains a challenge. As a step towards this need, silk-vaterite microspheres were fabricated and utilized as carriers to tune drug release. Doxorubicin (DOX) was loaded on the microspheres with high efficiency and the release behavior was regulated by tuning the microspheres via thermal processing.

Identifiers

PMID26693020
PMCPMC4675348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.