ArticleJournal of materials chemistry. B2015
Designer Hydrogels for Precision Control of Oxygen Tension and Mechanical Properties.
Article in Journal of materials chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments.International journal of molecular sciences · 2022Review
- Bioprinted microvasculature: progressing from structure to function.Biofabrication · 2022Review
- Engineering Tools for Regulating Hypoxia in Tumour Models.Journal of cellular and molecular medicine · 2021Review
- Discretizing Three-Dimensional Oxygen Gradients to Modulate and Investigate Cellular Processes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Gradient Hydrogels.Advances in biochemical engineering/biotechnology · 2021Article
- Engineering the Cellular Microenvironment of Post-infarct Myocardium on a Chip.Frontiers in cardiovascular medicine · 2021Review
- Hydrogel Network Dynamics Regulate Vascular Morphogenesis.Cell stem cell · 2020Article
- Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology.Advanced healthcare materials · 2020Review
- Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs.Advanced biosystems · 2019Article
- Stabilization of enzyme-immobilized hydrogels for extended hypoxic cell culture.Emergent materials · 2019Article
- Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis.Science advances · 2019Article
- Dual IFN-γ/hypoxia priming enhances immunosuppression of mesenchymal stromal cells through regulatory proteins and metabolic mechanisms.Journal of immunology and regenerative medicine · 2018Article
- ONature protocols · 2017Article
- Engineered Polymeric Hydrogels for 3D Tissue Models.Polymers · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Oxygen levels and mechanical properties provide vital cues to regulate myriad cellular functions and stem cell fate decisions. Here, we present a hybrid hydrogel system in which we can control independently oxygen levels and mechanical properties. We designed, synthesized and analyzed a hybrid hydrogel system comprised of two polymer backbones, gelatin and dextran. Both polymers were crosslinked via a laccase-mediated, oxygen consuming reaction. By specifically controlling the concentration of phenolic molecules available to react in our hydrogel, we could precisely control the time in which the hydrogel remained hypoxic (TH). We were able to achieve a range of TH from the order of minutes to greater than 10 hours. Additionally, by incorporating a secondary crosslinker, transglutaminase, mechanical properties could be adjusted in a user-defined fashion, with dynamic elastic modulus (G') values ranging from <20 Pa to >1 kPa. Importantly, oxygen levels and substrate mechanical properties could be individually tuned and decoupled in our hybrid hydrogels, while retaining the potential to study possible synergistic effects between the two parameters. By precisely controlling oxygen tension and mechanical properties, we expect that research utilizing the new hybrid hydrogels will enhance our understanding of the complex 3D cellular processes mediated by each parameter individually and may also hold clinical interest as acellular therapies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.