Evidence map›Paper›PMID 26692950›Full record

ArticleAmerican journal of translational research2015

Plasma microRNAs to predict the response of radiotherapy in esophageal squamous cell carcinoma patients.

Qi Yu, Bingxin Li, Ping Li, Zeliang Shi, Amanda Vaughn, Liucun Zhu, Shen Fu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.Clinical and translational gastroenterology · 2018
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. MicroRNA: a novel implication for damage and protection against ionizing radiation.Environmental science and pollution research international · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Angiopoietin-1 facilitates recovery of hematopoiesis in radiated mice.American journal of translational research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qi YuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center Shanghai, China ; Department of Oncology, Shanghai Medical College, Fudan University Shanghai, China.
Bingxin LiDepartment of Radiation Oncology, Central Hospital of Lishui/The Five Affiliated Hospital of Wenzhou Medical University Lishui, China ; Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Ping LiDepartment of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Zeliang ShiDepartment of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Amanda VaughnDepartment of Molecular Biosciences, Institute of Cellular and Molecular Biology, The University of Texas Austin, USA.
Liucun ZhuSchool of Life Sciences, Shanghai University Shanghai, China.
Shen FuDepartment of Oncology, Shanghai Medical College, Fudan University Shanghai, China ; Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China ; Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center Shanghai, China.
Shanghai Jiao Tong University · CNShanghai Sixth People's Hospital · CNShanghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although microRNAs (miRNAs) play an important role in esophageal squamous cell carcinoma (ESCC), their roles in radiotherapy response remain unexplored. Our study aims to investigate whether plasma miRNAs can be used as predictors of radiotherapy outcome in ESCC patients. We selected nine miRNAs, which were reported to be associated with carcinogenesis or radiobiology of ESCC, as the targets of our study. Plasma miRNA expression was investigated with 24 subjects (pre-, at the first week and post-radiotherapy). Tumor radiographic response and 3-year overall survival were used to evaluate the response. The results showed that the level of miR-16 in the patients with good outcome was significantly higher than that in the patients with poor outcome (P < 0.05, AUC: 0.762) at the post-radiotherapy. We also found that the variation tendency of miRNA expression were related to its radiotherapy response. Moreover, miR-16 levels increased by more than 2-fold following treatment, which were shown to be associated with longer OS (log-rank P = 0.009). In conclusion, miR-16 has considerable clinical value in predicting radiotherapy outcomes for ESCC patients.

Indexed as

Esophageal squamous cell carcinomamicroRNAsplasmaradiotherapy

Identifiers

PMID26692950
PMCPMC4656783
OpenAlexW2216643139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.