ArticleAmerican journal of translational research2015
miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- 6-gingerol promotes apoptosis of ovarian cancer cells through miR-506/Gli3 signaling pathway activation.Frontiers in oncology · 2025Article
- Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases.Molecular medicine (Cambridge, Mass.) · 2024Review
- MicroRNA-98 as a novel diagnostic marker and therapeutic target in cancer patients.Discover oncology · 2024Review
- Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma.Cells · 2024Review
- IGF2BPs as novel mGenes & diseases · 2024Review
- The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing.Cell communication and signaling : CCS · 2023Review
- The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches.Cancers · 2023Review
- Interaction between m6A methylation and noncoding RNA in glioma.Cell death discovery · 2022Review
- The Roles and Regulation of mBiomedicines · 2022Review
- MicroRNA-30e-3p inhibits glioma development and promotes drug sensitivity to temozolomide treatment via targeting canopy FGF signaling regulator 2.Cell cycle (Georgetown, Tex.) · 2021Article
- Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway.Journal of cellular and molecular medicine · 2021Article
- LINC01433 targets miR-506-3p to promote the biological progress of nasopharyngeal carcinoma cells.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- m6A modification in RNA: biogenesis, functions and roles in gliomas.Journal of experimental & clinical cancer research : CR · 2020Review
- The Emerging Roles of RNA Modifications in Glioblastoma.Cancers · 2020Review
- Overexpression of MiR-506 in Jurkat (Acute T Cell Leukemia) Cell Line.Iranian journal of pathology · 2020Article
- B3GNT3, a Direct Target of miR-149-5p, Promotes Lung Cancer Development and Indicates Poor Prognosis of Lung Cancer.Cancer management and research · 2020Article
- Multiomics profile and prognostic gene signature of m6A regulators in uterine corpus endometrial carcinoma.Journal of Cancer · 2020Article
- Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferationWorld journal of gastroenterology · 2019Article
- miR-506 regulates cell proliferation and apoptosis by affecting RhoA/ROCK signaling pathway in hepatocellular carcinoma cells.International journal of clinical and experimental pathology · 2019Article
- MiR-506 Suppresses Colorectal Cancer Development by Inhibiting Orphan Nuclear Receptor NR4A1 Expression.Journal of Cancer · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence has indicated that microRNAs (miRNAs) play an essential role in cancers. Deregulation of miR-506 was reported in several cancers. However, the expression and function of miR-506 in glioblastoma remain unclear. Our data showed that the level of miR-506 was downregulated in glioblastoma tissues and cell lines. Overexpression of miR-506 repressed cell growth, blocked G1/S transition, and suppressed cell invasion in glioblastoma cell. Moreover, IGF2BP1 was a direct target of miR-506 in glioblastoma cells. Knockdown of IGF2BP1 recapitulated the anti-proliferative and anti-invasive effects of miR-506, whereas IGF2BP1 overexpression antagonized the tumor-suppressive function of miR-506. Our data showed that miRNA-506 played a tumor suppressor gene role in human glioblastoma by regulating IGF2BP1 gene and might be a new therapeutic target of human glioblastoma.
Indexed as
Identifiers
26692944PMC4656777W2305853311What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.