ArticleAmerican journal of translational research2015
Inhibition of the growth of non-small cell lung cancer by miRNA-1271.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Kidney-specific HIF-1α-dependent ARL10/miR-1271-5p overexpression in clear cell renal cell carcinoma.British journal of cancer · 2026Article
- MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance.Discover oncology · 2025Review
- Article
- Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers.NAR cancer · 2020Article
- Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis.Aging · 2020Article
- microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ.Journal of translational medicine · 2020Article
- Estrogen receptor-α-miR-1271-SNAI2 feedback loop regulates transforming growth factor-β-induced breast cancer progression.Journal of experimental & clinical cancer research : CR · 2019Article
- miR-1271 inhibits growth, invasion and epithelial-mesenchymal transition by targeting ZEB1 in ovarian cancer cells.OncoTargets and therapy · 2019Article
- Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271.Molecular medicine reports · 2018Article
- LncRNA-DANCR contributes to lung adenocarcinoma progression by sponging miR-496 to modulate mTOR expression.Journal of cellular and molecular medicine · 2018Article
- Expression and role of microRNA-1271 in the pathogenesis of osteosarcoma.Experimental and therapeutic medicine · 2018Article
- miR-1271 inhibits ERα expression and confers letrozole resistance in breast cancer.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-small cell lung cancer (NSCLC) is a common lung cancer of high incidence. Since NSCLCs often grow rapidly, it is critical to elucidate the underlying mechanisms. Previous studies have shown that microRNAs (miRNAs) play critical roles in the carcinogenesis of NSCLC. Specifically, miR-1271 has been shown to downregulate in NSCLC cells. However, whether the downregulation of miR-1271 relates to carcinogenesis of NSCLC is unknown. Here, we analyzed the levels of miR-1271 and mTor in NSCLC specimens and studied their correlation. We performed bioinformatics analysis and luciferase-reporter assay to study the association of miR-1271 with mTor mRNA. We analyzed miR-1271 levels in NSCLC cells and studied their effects on mTor levels. The growth of miR-1271-modified NSCLC cells was evaluated in vitro in an MTT assay, and in vivo by bioluminescence. We detected significantly higher levels of mTor and significantly lower levels of miR-1271 in the NSCLC specimens, compared to the paired non-tumor lung tissues. We found that miR-1271 bound to the 3'UTR of mTor mRNA to prevent its translation. Overexpression of miR-1271 in NSCLC cells decreased mTor protein levels, whereas inhibition of miR-1271 increased mTor protein levels, without affecting mTor transcripts. Moreover, overexpression of miR-1271 suppressed the NSCLC growth in vitro and in vivo, while inhibition of miR-1271 significantly increased NSCLC growth. Together, these data suggest that in NSCLC, miR-1271 may inhibit the cancer cell growth through mTor suppression.
Indexed as
Identifiers
26692935PMC4656768W2200060228What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.