ArticlePolish journal of radiology2015
PH Measurements of the Brain Using Phosphorus Magnetic Resonance Spectroscopy ((31)PMRS) in Healthy Men - Comparison of Two Analysis Methods.
Article in Polish journal of radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Structural Descriptors and Antioxidant Activity Markers of 4-[4-(2-Aminoethoxy)benzyl]aniline.Antioxidants (Basel, Switzerland) · 2026Article
- Use ofAging cell · 2023Article
- Brain pH Measurement Using AACID CEST MRI Incorporating the 2 ppm Amine Resonance.Tomography (Ann Arbor, Mich.) · 2022Article
- 31-Phosphorus Magnetic Resonance Spectroscopy in Evaluation of Glioma and Metastases in 3T MRI.The Indian journal of radiology & imaging · 2021Article
- Quantification of tumor microenvironment acidity in glioblastoma using principal component analysis of dynamic susceptibility contrast enhanced MR imaging.Scientific reports · 2021Article
- Magnetic Resonance pH Imaging in Stroke - Combining the Old With the New.Frontiers in physiology · 2021Article
- Short-term meditation training influences brain energy metabolism: A pilot study onBrain and behavior · 2021Article
- Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies.International journal of molecular sciences · 2019Review
- The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging.Investigational new drugs · 2019Article
- In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide.International journal of clinical oncology · 2018Article
- Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla.Journal of neuro-oncology · 2018Article
- [Technique of proton and phosphorous MR spectroscopy].Der Radiologe · 2017Review
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3 authors.
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Abstract
backgroundIntracellular pH provides information on homeostatic mechanisms in neurons and glial cells. The aim of this study was to define pH of the brain of male volunteers using phosphorus magnetic resonance spectroscopy ((31)PMRS) and to compare two methods of calculating this value. MATERIAL/
methodsIn this study, 35 healthy, young, male volunteers (mean age: 25 years) were examined by (31)PMRS in 1.5 T MR system (Signa Excite, GE). The FID CSI (Free Induction Decay Chemical Shift Imaging) sequence was used with the following parameters: TR=4000 ms, FA=90°, NEX=2. Volume of interest (VOI) was selected depending on the size of the volunteers' brain (11-14 cm(3), mean 11.53 cm(3)). Raw data were analyzed using SAGE (GE) software.
resultsBased on the chemical shift of peaks in the (31)PMRS spectrum, intracellular pH was calculated using two equations. In both methods the mean pH was slightly alkaline (7.07 and 7.08). Results were compared with a t-test. Significant difference (p<0.05) was found between these two methods.
conclusionsThe (31)PMRS method enables non-invasive in vivo measurements of pH. The choice of the calculation method is crucial for computing this value. Comparing the results obtained by different teams can be done in a fully credible way only if the calculations were performed using the same formula.
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