ArticlePharmacognosy research
Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens.
Article in Pharmacognosy research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Antihyperglycemic and anti-type 2 diabetic activity of marine hydroquinone isolated from brown algae (Journal of traditional and complementary medicine · 2023Article
- In Vitro α-Amylase and α-Glucosidase Inhibitory Activity of Green SeaweedPlants (Basel, Switzerland) · 2023Article
- Hypoglycaemic Molecules for the Management of Diabetes Mellitus from Marine Sources.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Effects of In Vitro Digestion on Anti-α-Amylase and Cytotoxic Potentials ofMolecules (Basel, Switzerland) · 2022Article
- Seaweeds as Ingredients to Lower Glycemic Potency of Cereal Foods Synergistically-A Perspective.Foods (Basel, Switzerland) · 2022Article
- Effect of theEvidence-based complementary and alternative medicine : eCAM · 2022Article
- α-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects ofPharmaceutical biology · 2021Article
- Pharmacological and natural products diversity of the brown algae genusRSC advances · 2020Review
- The inhibitory effect of some natural bioactive compounds against SARS-CoV-2 main protease: insights from molecular docking analysis and molecular dynamic simulation.Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering · 2020Article
- High-Performance Thin-Layer Chromatography Hyphenated with Microchemical and Biochemical Derivatizations in Bioactivity Profiling of Marine Species.Marine drugs · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio-stimulants even a component of animal foods.
objectiveIn this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations. MATERIALS AND
methodsFor that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods.
resultsSix sterols, fucosterol (1), 24(S)-hydroxy-24-vinylcholesterol (2), 24(R)-hydroxy-24-vinylcholesterol (3), stigmasterol (4), β-sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including (1)H-NMR, (13)C-NMR and mass spectroscopy. In vitro alpha-amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC50 = 8.9 ± 2.4 mg/mL) of the enzyme compared to acarbose as a positive control.
conclusionVarious biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti-diabetic investigations in animals and human.
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