ReviewObesity (Silver Spring, Md.)2016
NIH working group report-using genomic information to guide weight management: From universal to precision treatment.
Review in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Web-based Weight Loss Intervention
Precision Nutrition Impact on Health-Related Behavior Change in Active Duty Service Members
Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.Human molecular genetics · 2019Pooled it
- Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- The effect of diets with different inflammatory scores on inflammation and sleep in obese subjects: a randomized controlled trial.Revista da Associacao Medica Brasileira (1992) · 2024Trial
- Physician weight influences responses to a public health message about the genetics of obesity.Patient education and counseling · 2023Trial
- Infancy and Childhood Obesity Grade Predicts Weight Loss in Adulthood: The ONTIME Study.Nutrients · 2021Trial
- Weight-related genomic information and provider communication approach: looking through the lens of patient race.Personalized medicine · 2019Trial
- Trial
- Clinical-genetic predisposition and medium-term outcomes after bariatric surgery: A 5-year validation of the OBEGEN score.Obesity pillars · 2026Article
- Obesity and Depression: A Pathophysiotoxic Relationship.International journal of molecular sciences · 2025Review
- Quality of Life, Physical Activity, and Mental and Physical Health Status in Croatian Middle-Aged and Elderly Population.Healthcare (Basel, Switzerland) · 2025Article
- Exploring the link between dietary inflammatory index, inflammatory biomarkers, and sleep quality in adults with obesity: a pilot investigation.International journal of obesity (2005) · 2025Article
- Obesity as a Disease: A Primer on Clinical and Physiological Insights.Methodist DeBakey cardiovascular journal · 2025Review
- Race, Ethnicity, and Geography as Determinants of Excessive Weight and Low Physical Activity in Pediatric Population: Protocol for Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2024Article
- Bariatric surgery and diabetes: Current challenges and perspectives.World journal of diabetes · 2024Review
- An epigenome-wide association study of waist circumference in Chinese monozygotic twins.International journal of obesity (2005) · 2024Article
- Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records.Nature communications · 2024Article
- PACE: a Novel Eating Behavior Phenotype to Assess Risk for Obesity in Middle Childhood.The Journal of nutrition · 2024Article
- Role of Endogenous Opioids in the Pathophysiology of Obesity and Eating Disorders.Advances in neurobiology · 2024Review
- Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster.PloS one · 2024Article
- Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases.Antioxidants (Basel, Switzerland) · 2023Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
objectivePrecision medicine utilizes genomic and other data to optimize and personalize treatment. Although more than 2,500 genetic tests are currently available, largely for extreme and/or rare phenotypes, the question remains whether this approach can be used for the treatment of common, complex conditions like obesity, inflammation, and insulin resistance, which underlie a host of metabolic diseases.
methodsThis review, developed from a Trans-NIH Conference titled "Genes, Behaviors, and Response to Weight Loss Interventions," provides an overview of the state of genetic and genomic research in the area of weight change and identifies key areas for future research.
resultsAlthough many loci have been identified that are associated with cross-sectional measures of obesity/body size, relatively little is known regarding the genes/loci that influence dynamic measures of weight change over time. Although successful short-term weight loss has been achieved using many different strategies, sustainable weight loss has proven elusive for many, and there are important gaps in our understanding of energy balance regulation.
conclusionsElucidating the molecular basis of variability in weight change has the potential to improve treatment outcomes and inform innovative approaches that can simultaneously take into account information from genomic and other sources in devising individualized treatment plans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.