ArticlePlanta medica2016
Comparison of Flow Injection MS, NMR, and DNA Sequencing: Methods for Identification and Authentication of Black Cohosh (Actaea racemosa).
Article in Planta medica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- One-class modeling for verification of botanical identity: a review.Frontiers in pharmacology · 2025Review
- Integrating DNA Barcoding Within an Orthogonal Approach for Herbal Product Authentication: A Narrative Review.Phytochemical analysis : PCA · 2025Review
- Variation in Botanical Reference Materials: Similarity of Actaea Racemosa Analyzed by Flow Injection Mass Spectrometry.Journal of AOAC International · 2024Article
- Botanical Authentication Using One-Class Modeling.Journal of AOAC International · 2023Article
- Botanical Ingredient Forensics: Detection of Attempts to Deceive Commonly Used Analytical Methods for Authenticating Herbal Dietary and Food Ingredients and Supplements.Journal of natural products · 2023Review
- Benefits of Black Cohosh (Pharmaceuticals (Basel, Switzerland) · 2022Review
- Working with the natural complexity: Selection and characterization of black cohosh root extract for use in toxicology testing.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022Article
- Quantification of Actaea racemosa L. (black cohosh) from some of its potential adulterants using qPCR and dPCR methods.Scientific reports · 2021Article
- Chemometric-Guided Approaches for Profiling and Authenticating Botanical Materials.Frontiers in nutrition · 2021Review
- The Importance of Reference Materials and Method Validation for Advancing Research on the Health Effects of Dietary Supplements and Other Natural Products.Frontiers in nutrition · 2021Review
- Analytical Challenges and Metrological Approaches to Ensuring Dietary Supplement Quality: International Perspectives.Frontiers in pharmacology · 2021Review
- Identification of adulteration in botanical samples with untargeted metabolomics.Analytical and bioanalytical chemistry · 2020Article
- Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Selection and characterization of botanical natural products for research studies: a NaPDI center recommended approach.Natural product reports · 2019Review
- Integrated analytical assets aid botanical authenticity and adulteration management.Fitoterapia · 2018Review
- How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Article
- Feruloyl dopamine-O-hexosides are efficient marker compounds as orthogonal validation for authentication of black cohosh (Actaea racemosa)-an UHPLC-HRAM-MS chemometrics study.Analytical and bioanalytical chemistry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Flow injection mass spectrometry and proton nuclear magnetic resonance spectrometry, two metabolic fingerprinting methods, and DNA sequencing were used to identify and authenticate Actaea species. Initially, samples of Actaea racemosa from a single source were distinguished from other Actaea species based on principal component analysis and soft independent modeling of class analogies of flow injection mass spectrometry and proton nuclear magnetic resonance spectrometry metabolic fingerprints. The chemometric results for flow injection mass spectrometry and proton nuclear magnetic resonance spectrometry agreed well and showed similar agreement throughout the study. DNA sequencing using DNA sequence data from two independent gene regions confirmed the metabolic fingerprinting results. Differences were observed between A. racemosa samples from four different sources, although the variance within species was still significantly less than the variance between species. A model based on the combined A. racemosa samples from the four sources consistently permitted distinction between species. Additionally, the combined A. racemosa samples were distinguishable from commercial root samples and from commercial supplements in tablet, capsule, or liquid form. DNA sequencing verified the lack of authenticity of the commercial roots but was unsuccessful in characterizing many of the supplements due to the lack of available DNA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.