ArticlePloS one2015
DNA-Binding Motif of the Imprinted Transcription Factor PEG3.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences.International journal of molecular sciences · 2025Review
- Article
- A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- PEG3 controls lipogenesis through ACLY.PloS one · 2021Article
- Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy.Matrix biology : journal of the International Society for Matrix Biology · 2019Review
- The imprinted gene Pw1/Peg3 regulates skeletal muscle growth, satellite cell metabolic state, and self-renewal.Scientific reports · 2018Article
- Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers.Human molecular genetics · 2018Article
- Allele and dosage specificity of the Peg3 imprinted domain.PloS one · 2018Article
- Oxytocin receptor is regulated by Peg3.PloS one · 2018Article
- Article
- Reduced expression of Paternally Expressed Gene-3 enhances somatic cell reprogramming through mitochondrial activity perturbation.Scientific reports · 2017Article
- Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis.The Journal of biological chemistry · 2017Article
- PEG3 control on the mammalian MSL complex.PloS one · 2017Article
- Parental and sexual conflicts over the Peg3 imprinted domain.Scientific reports · 2016Article
- PEG3 Interacts with KAP1 through KRAB-A.PloS one · 2016Article
- Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain.PloS one · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Peg3 is an imprinted gene that is predicted to encode a DNA-binding zinc finger protein. This was previously demonstrated through Chromatin ImmunoPrecipitation-based Sequencing experiments. In the current study, we reanalyzed the previous ChIP-Seq results and further characterized the DNA-binding motif of PEG3. According to the results, PEG3 binds to the promoters and enhancers of a subset of genes that are closely associated with the known functions of Peg3. Some of these identified targets include Tufm, Mrpl45, Cry2, Per1, Slc25a29 and Slc38a2. With this set of targets, we derived a DNA-binding motif of PEG3, 5'-GTGGCAGT-3', which also provides a tabulated matrix that can be used for predicting other unknown genomic targets. Among the newly identified targets, we analyzed in detail the two loci, Slc38a2 and Slc38a4, which are known to be involved in neutral amino acid transport. The results indicated that PEG3 likely functions as a transcriptional repressor for these two loci. Overall, the current study provides a set of genomic targets and also redefines the DNA-binding motif for the imprinted transcription factor PEG3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.