ArticleEuropean journal of immunology2016
Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system.
Article in European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice.Nature communications · 2026Article
- Activation and Functions of Col6a1+ Fibroblasts in Colitis-Associated Cancer.International journal of molecular sciences · 2023Article
- Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6CNature communications · 2022Article
- IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer.NPJ breast cancer · 2021Article
- Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EPThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier.Acta neuropathologica · 2020Article
- Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease.Journal of molecular medicine (Berlin, Germany) · 2020Review
- Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.The Journal of experimental medicine · 2019Article
- Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction.JCI insight · 2019Article
- Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons.Brain, behavior, and immunity · 2019Article
- Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.Cell reports · 2019Article
- Cutting Edge: IL-1R1 Mediates Host Resistance toJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.Nature medicine · 2018Article
- Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis.Radiation research · 2018Article
- New Insights into the Role of IL-1β in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.The Journal of experimental medicine · 2017Article
- IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells.The EMBO journal · 2017Article
- Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection.Journal of neuroinflammation · 2016Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
IL-1 is a key cytokine known to drive chronic inflammation and to regulate many physiological, immunological, and neuroimmunological responses via actions on diverse cell types of the body. To determine the mechanisms of IL-1 actions as part of the inflammatory response in vivo, we generated a conditional IL-1 receptor 1 (IL-1R1) mouse mutant using the Cre/LoxP system (IL-1R1(fl/fl) ). In the mutant generated, exon 5, which encodes part of the extracellular-binding region of the receptor, is flanked by LoxP sites, thereby inactivating the two previously described functional IL-1R1 gene transcripts after Cre-mediated recombination. Using keratin 14-Cre driver mice, new IL-1R1 deficient (-/-) mice were subsequently generated, in which all signaling IL-1 receptor isoforms are deleted ubiquitously. Furthermore, using vav-iCre driver mice, we deleted IL-1 receptor isoforms in the hematopoietic system. In these mice, we show that both the IL-17 and IL-22 cytokine response is reduced, when mice are challenged by the helminth Trichuris muris. We are currently crossing IL-1R1(fl/fl) mice with different Cre-expressing mice in order to study mechanisms of acute and chronic inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.