Trial reportPloS one2015
Re-Examining the Association between Vitamin D and Childhood Caries.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03158155 (Prevalence of Early Childhood Caries in Egyptian Children With Serum Vitamin D Deficiency.), which is not on this map. Cited by 23 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence of Early Childhood Caries in Egyptian Children With Serum Vitamin D Deficiency.
Who cites it
23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Vitamin D and human health: evidence from Mendelian randomization studies.European journal of epidemiology · 2024Pooled it
- Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- The Impact of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Review.Nutrients · 2023Pooled it
- Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Prenatal or Childhood Serum Levels of Vitamin D and Dental Caries in Paediatric Patients: A Systematic Review.Oral health & preventive dentistry · 2020Pooled it
- The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Evidence Drift and Causal Maturation Drift in Pediatric Health Research: A Dual-Drift Framework and Preliminary Appraisal Instruments for Inferential Fidelity.Children (Basel, Switzerland) · 2026Article
- Serum 25(OH)D Levels and Dental Caries Experience in Children: A Cross-Sectional Study.Oral health & preventive dentistry · 2026Article
- Evidence Drift in Early Childhood Caries Research: A Conceptual Six-Domain Causal-Translation Framework.Children (Basel, Switzerland) · 2026Article
- Dietary diversity and food groups associated with early childhood caries in a suburban community in Nigeria.BMC oral health · 2025Article
- Expert consensus on the treatment of oral diseases in pregnant women and infants.International journal of oral science · 2025Review
- The Role of Serum Vitamin D Levels and Vitamin D Receptor (Children (Basel, Switzerland) · 2024Article
- The Impact of Vitamin Deficiencies on Oral Manifestations in Children.Dentistry journal · 2024Review
- Are childhood oral health behaviours and experiences associated with dental anxiety in adolescence?International journal of paediatric dentistry · 2023Article
- Vitamin D, pregnancy and caries in children in the INMA-Asturias birth cohort.BMC pediatrics · 2021Article
- Associations Between Prenatal, Perinatal, and Early Childhood Vitamin D Status and Risk of Dental Caries at 6 Years.The Journal of nutrition · 2021Article
- Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area.Nutrients · 2021Article
- Vitamin D Deficiency and Oral Health: A Comprehensive Review.Nutrients · 2020Review
- Association of Maternal Vitamin D Deficiency with Early Childhood Caries.Journal of dental research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear.
objectiveTo determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the requirement for a dental general anesthetic.
designA Mendelian randomization study was undertaken, using genetic variants known to be associated with circulating 25-hydroxyvitamin D concentrations in 5,545 European origin children from the South West of England. Data on caries and related characteristics were obtained from parental and child completed questionnaires between 38 and 91 months and clinical assessments in a random 10% sample at 31, 44 and 61 months.
resultsIn multivariable confounder adjusted analyses no strong evidence for an association of 25-hydroxyvitamin D with caries experience or severity was found but there was evidence for an association with early caries onset, or having a general anesthetic for dental problems. In Mendelian randomization analysis the odds ratio for caries experience per 10 nmol/L increase in 25-hydroxyvitamin D was 0.93 (95% confidence interval: 0.83, 1.05; P = 0.26) and the odds ratio for dental general anaesthetic per 10 nmol/L increase in 25-hydroxyvitamin D was 0.96 (95% confidence interval: 0.75, 1.22; P = 0.72).
conclusionsThis Mendelian randomization study provides little evidence to support an inverse causal effect of 25-hydroxyvitamin D on dental caries. However, the estimates are imprecise and a larger study is required to refine these analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.