Evidence map›Paper›PMID 26691640›Full record

ArticlePloS one2015

Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han.

Xijia Xu, Shiping Xie, Xiaomeng Shi, Jie Lv, Xiaowei Tang, Xiaolan Wang, Shuiping Lu, Mingzhong Wang, Xiaobing Zhang, Jing Sun and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Xijia XuDepartment of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Shiping XieDepartment of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Xiaomeng ShiDepartment of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jie LvDepartment of Psychiatry, Nanjing Qinglongshan Mental Hospital, Nanjing, 211123, China.
Xiaowei TangDepartment of Psychiatry, Affiliated Wutaishan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, China.
Xiaolan WangDepartment of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Shuiping LuDepartment of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Mingzhong WangDepartment of Psychiatry, Nanjing Qinglongshan Mental Hospital, Nanjing, 211123, China.
Xiaobing ZhangDepartment of Psychiatry, Affiliated Wutaishan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, China.
Jing SunDepartment of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Hui YaoDepartment of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Nanjing Brain Hospital · CNNanjing Medical University · CNYangzhou University · CNNanjing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. HRE was also seen in the genomes of patients suffering from several other degenerative diseases. However, whether it is present in the treatment-resistant schizophrenia patients remains unknown. Genotyping 386 patients suffering from treatment-resistant schizophrenia using the method of Repeat-Primed PCR, we reported here that no HRE was detected in the patients of Chinese Han.

Indexed as

DNA Repeat ExpansionAdultAgedAged, 80 and overAntipsychotic AgentsAsian PeopleC9orf72 ProteinCase-Control StudiesFemaleHumansMaleMiddle AgedProteinsSchizophreniaYoung AdultAntipsychotic AgentsC9orf72 ProteinC9orf72 protein, humanProteins

Identifiers

PMID26691640
PMCPMC4687052
OpenAlexW2303109192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.