Evidence map›Paper›PMID 26691548›Full record

SynthesisAIDS (London, England)2016

Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: a meta-analysis.

Lesley S Park, Raúl U Hernández-Ramírez, Michael J Silverberg, Kristina Crothers, Robert Dubrow

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 8 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 8 syntheses or guidelines pooled it, 174 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Integrating HIV and substance use services: a systematic review.Journal of the International AIDS Society · 2017
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lesley S ParkaDivision of Endocrinology, Gerontology, and Metabolism, Department of Medicine and Division of Epidemiology, Department of Health Policy and Research, Stanford University School of Medicine, Stanford, CaliforniabDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale School of Medicine, New Haven, ConnecticutcDivision of Research, Kaiser Permanente, Oakland, CaliforniadDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington, USA.*Lesley S. Park and Raúl U. Hernández-Ramírez contributed equally to this article.
Raúl U Hernández-Ramírez
Michael J Silverberg
Kristina Crothers
Robert Dubrow
Apple (Israel) · ILStanford Medicine · US

Funding

Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI John Edward Pachankis · 2001 to 2026
$48.5M
INTERDISCIPLINARY HIV PREVENTION TRAINING PROGRAMT32MH020031 · NIMH · YALE UNIVERSITY · PI Trace S Kershaw · 1999 to 2026
$12.1M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Diabetes, Endocrinology and Metabolism Training GrantT32DK007217 · NIDDK · STANFORD UNIVERSITY · PI Justin Pierce Annes, David Matthew Maahs · 1987 to 2026
$7.2M
Benefits and Harms of Lung Cancer Screening in HIV InfectionR01CA173754 · NCI · UNIVERSITY OF WASHINGTON · PI BRAITHWAITE, RONALD SCOTT, CROTHERS, KRISTINA ANNE · 2013 to 2017
$2.5M
Antiretroviral Therapy Strategies to Lower Cancer Risk in HIV-Infected PersonsR01CA165937 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI DUBROW, ROBERT D, SILVERBERG, MICHAEL J · 2012 to 2015
$2.4M
HIV Infection, Antiretroviral Therapy, Cancer Incidence and ProgressionK01AI071725 · NIAID · KAISER FOUNDATION RESEARCH INSTITUTE · PI SILVERBERG, MICHAEL J · 2007 to 2011
$702k
Liver cancer risk and prevention among persons living with HIV/AIDSF31CA180775 · NCI · YALE UNIVERSITY · PI PARK, LESLEY SUEJEAN · 2013 to 2014
$81k
NCI NIH HHS F31 CA180775NCI NIH HHS F31-CA180775NCI NIH HHS R01 CA165937NCI NIH HHS R01-CA165937NCI NIH HHS R01 CA173754NCI NIH HHS R01-CA173754NIAAA NIH HHS 1U01-AA020790NIAAA NIH HHS U01 AA020790NIAID NIH HHS K01 AI071725NIAID NIH HHS K01-AI071725NIDDK NIH HHS 3T32-DK007217NIDDK NIH HHS T32 DK007217NIMH NIH HHS 5T32-MH020031NIMH NIH HHS P30 MH062294NIMH NIH HHS P30-MH062294NIMH NIH HHS T32 MH020031
6 · The paper itself

Abstract

objectiveThe burden of cancer among persons living with HIV/AIDS (PLWHA) is substantial and increasing. We assessed the prevalence of modifiable cancer risk factors among adult PLWHA in Western high-income countries since 2000.

designMeta-analysis.

methodsWe searched PubMed to identify articles published in 2011-2013 reporting prevalence of smoking, alcohol consumption, overweight/obesity, and infection with human papillomavirus (HPV), hepatitis C virus (HCV) and hepatitis B virus (HBV) among PLWHA. We conducted random effects meta-analyses of prevalence for each risk factor, including estimation of overall, sex-specific, and HIV-transmission-group-specific prevalence. We compared prevalence in PLWHA with published prevalence estimates in US adults.

resultsThe meta-analysis included 113 publications. Overall summary prevalence estimates were current smoking, 54% [95% confidence interval (CI) 49-59%] versus 20-23% in US adults; cervical high-risk HPV infection, 46% (95% CI 34-58%) versus 29% in US females; oral high-risk HPV infection, 16% (95% CI 10-23%) versus 4% in US adults; anal high-risk HPV infection (men who have sex with men), 68% (95% CI 57-79%), with no comparison estimate available; chronic HCV infection, 26% (95% CI 21-30%) versus 0.9% in US adults; and HBV infection, 5% (95% CI 4-5%) versus 0.3% in US adults. Overweight/obesity prevalence (53%; 95% CI 46-59%) was below that of US adults (68%). Meta-analysis of alcohol consumption prevalence was impeded by varying assessment methods. Overall, we observed considerable study heterogeneity in prevalence estimates.

conclusionPrevalence of smoking and oncogenic virus infections continues to be extraordinarily high among PLWHA, indicating a vital need for risk factor reduction efforts.

Indexed as

AdultDeveloped CountriesFemaleHepatitis B, ChronicHepatitis, ChronicHIV InfectionsHumansMaleMiddle AgedNeoplasmsPapillomavirus InfectionsPrevalenceRisk AssessmentRisk FactorsSmoking

Identifiers

PMID26691548
PMCPMC4689318
OpenAlexW2419386918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.