ArticleNeuroImage2016
Kernel regression estimation of fiber orientation mixtures in diffusion MRI.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge.Journal of magnetic resonance imaging : JMRI · 2020Pooled it
- Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Life After Mild Traumatic Brain Injury: Widespread Structural Brain Changes Associated With Psychological Distress Revealed With Multimodal Magnetic Resonance Imaging.Biological psychiatry global open science · 2023Article
- More extensive white matter disruptions present in untreated obstructive sleep apnea than we thought: A large sample diffusion imaging study.Human brain mapping · 2023Article
- White matter microstructure in habit and reward circuits in anorexia nervosa: Insights from a neurite orientation dispersion and density imaging study.Acta psychiatrica Scandinavica · 2023Article
- White matter microstructure and connectivity changes after surgery in male adults with obstructive sleep apnea: recovery or reorganization?Frontiers in neuroscience · 2023Article
- Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates.Frontiers in neurology · 2022Review
- Somatotopic Organization of Hyperdirect Pathway Projections From the Primary Motor Cortex in the Human Brain.Frontiers in neurology · 2022Article
- Microstructural properties within the amygdala and affiliated white matter tracts across adolescence.NeuroImage · 2021Article
- Tractography Processing with the Sparse Closest Point Transform.Neuroinformatics · 2021Article
- Tract-specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke.Brain and behavior · 2021Article
- The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study.Progress in neurobiology · 2020Article
- Magnitude and timing of major white matter tract maturation from infancy through adolescence with NODDI.NeuroImage · 2020Article
- Dietary Fructose Intake and Hippocampal Structure and Connectivity during Childhood.Nutrients · 2020Article
- Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults.Brain imaging and behavior · 2019Article
- Clinical 7 T MRI: Are we there yet? A review about magnetic resonance imaging at ultra-high field.The British journal of radiology · 2019Review
- White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa.Brain imaging and behavior · 2018Article
- Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging.Psychiatry research. Neuroimaging · 2018Article
- Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients.Frontiers in neuroinformatics · 2018Article
- Topological Organization of Whole-Brain White Matter in HIV Infection.Brain connectivity · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We present and evaluate a method for kernel regression estimation of fiber orientations and associated volume fractions for diffusion MR tractography and population-based atlas construction in clinical imaging studies of brain white matter. This is a model-based image processing technique in which representative fiber models are estimated from collections of component fiber models in model-valued image data. This extends prior work in nonparametric image processing and multi-compartment processing to provide computational tools for image interpolation, smoothing, and fusion with fiber orientation mixtures. In contrast to related work on multi-compartment processing, this approach is based on directional measures of divergence and includes data-adaptive extensions for model selection and bilateral filtering. This is useful for reconstructing complex anatomical features in clinical datasets analyzed with the ball-and-sticks model, and our framework's data-adaptive extensions are potentially useful for general multi-compartment image processing. We experimentally evaluate our approach with both synthetic data from computational phantoms and in vivo clinical data from human subjects. With synthetic data experiments, we evaluate performance based on errors in fiber orientation, volume fraction, compartment count, and tractography-based connectivity. With in vivo data experiments, we first show improved scan-rescan reproducibility and reliability of quantitative fiber bundle metrics, including mean length, volume, streamline count, and mean volume fraction. We then demonstrate the creation of a multi-fiber tractography atlas from a population of 80 human subjects. In comparison to single tensor atlasing, our multi-fiber atlas shows more complete features of known fiber bundles and includes reconstructions of the lateral projections of the corpus callosum and complex fronto-parietal connections of the superior longitudinal fasciculus I, II, and III.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.