ArticleScientific reports2015
Efficient chemo-enzymatic gluten detoxification: reducing toxic epitopes for celiac patients improving functional properties.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 63 citations in OpenAlex.
- Current challenges of alternative proteins as future foods.NPJ science of food · 2024Review
- Emerging Chemical, Biochemical, and Non-Thermal Physical Treatments in the Production of Hypoallergenic Plant Protein Ingredients.Foods (Basel, Switzerland) · 2024Review
- Low Gluten Beers Contain Variable Gluten and Immunogenic Epitope Content.Foods (Basel, Switzerland) · 2023Article
- Type 2 Transglutaminase in Coeliac Disease: A Key Player in Pathogenesis, Diagnosis and Therapy.International journal of molecular sciences · 2022Review
- The 10,000-Year Success Story of Wheat!Foods (Basel, Switzerland) · 2021Review
- The evaluation of part-baked frozen bread produced from wheat flour and guar gum in the diet of celiac patients.Journal of food science and technology · 2021Article
- Characterizing the Rheological and Bread-Making Properties of Wheat Flour Treated by "Gluten FriendlyFoods (Basel, Switzerland) · 2021Article
- Wheat-induced food allergy in childhood: ancient grains seem no way out.European journal of nutrition · 2020Article
- Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?Nutrients · 2020Article
- Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them.Frontiers in nutrition · 2020Review
- Food additives can act as triggering factors in celiac disease: Current knowledge based on a critical review of the literature.World journal of clinical cases · 2019Review
- Abrogation of Immunogenic Properties of Gliadin Peptides through Transamidation by Microbial Transglutaminase Is Acyl-Acceptor Dependent.Journal of agricultural and food chemistry · 2017Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein engineering of gluten, the exogenous effector in celiac disease, seeking its detoxification by selective chemical modification of toxic epitopes is a very attractive strategy and promising technology when compared to pharmacological treatment or genetic engineering of wheat. Here we present a simple and efficient chemo-enzymatic methodology that decreases celiac disease toxic epitopes of gluten proteins improving its technological value through microbial transglutaminase-mediated transamidation of glutamine with n-butylamine under reducing conditions. First, we found that using low concentrations of amine-nucleophile under non-reducing conditions, the decrease in toxic epitopes is mainly due to transglutaminase-mediated cross-linking. Second, using high amine nucleophile concentrations protein cross-linking is substantially reduced. Third, reducing conditions increase 7-fold the transamidation reaction further decreasing toxic epitopes amount. Fourth, using n-butylamine improves gluten hydrophobicity that strengthens the gluten network. These results open the possibility of tailoring gluten for producing hypoallergenic flours while still taking advantage of the unique viscoelastic properties of gluten.
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