Evidence map›Paper›PMID 26691147›Full record

ReviewJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Emerging Concepts for the Endoscopic Management of Superficial Esophageal Adenocarcinoma.

Christina L Greene, Stephanie G Worrell, Stephen E Attwood, Parakrama Chandrasoma, Kenneth Chang, Tom R DeMeester, Reginald V Lord, Elizabeth Montgomery, Oliver Pech, John Vallone and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Endoscopic management of esophageal cancer.World journal of gastrointestinal oncology · 2019
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christina L GreeneDepartment of Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA, 90033, USA.
Stephanie G WorrellDepartment of Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA, 90033, USA.
Stephen E AttwoodDepartment of Surgery, North Tyneside General Hospital, Durham University, Tyne and Wear, UK.
Parakrama ChandrasomaDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Kenneth ChangDivision of Gastroenterology and Hepatology, University of California, Irvine, Orange, CA, USA.
Tom R DeMeesterDepartment of Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA, 90033, USA.
Reginald V LordDepartment of Surgery, Notre Dame University School of Medicine, Sydney, Sydney, Australia.
Elizabeth MontgomeryDepartment of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Oliver PechGastroenterology and Interventional Endoscopy, St. John of God Hospital, Teaching Hospital of the University of Regensburg, Regensburg, Germany.
John ValloneDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Michael ViethInstitute of Pathology, Klinikum Bayreuth, Preuschwitzerstr, Bayreuth, Germany.
Kenneth K WangDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Steven R DeMeesterDepartment of Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo Street, Suite 514, Los Angeles, CA, 90033, USA. stevenrdemeester@gmail.com.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
6 · The paper itself

Abstract

introductionEndoscopic therapy has revolutionized the treatment of Barrett's esophagus with high-grade dysplasia (HGD) or intramucosal adenocarcinoma by allowing preservation of the esophagus in many patients who would previously have had an esophagectomy. This paradigm shift initially occurred at high-volume centers in North America and Europe but now is becoming mainstream therapy. There is a lack of uniform guidelines and algorithms for the management of these patients. Our aim was to review important concepts and pitfalls in the endoscopic management of superficial esophageal adenocarcinoma.

methodsA small group colloquium consisting of gastroenterologists, surgeons, and pathologists reviewed published data and discussed personal and institutional experiences with endotherapy for HGD and superficial esophageal adenocarcinoma.

resultsThe group reviewed data and provided recommendations and management algorithms for seven areas pertaining to endoscopic therapy for Barrett's HGD and superficial adenocarcinoma: (1) patient selection and evaluation; (2) imaging and biopsy techniques; (3) devices; (4) indications for resection versus ablation; (5) ER specimen handling, processing, and pathologic evaluation; (6) patient care and follow-up after endoscopic therapy; and (7) complications of endoscopic therapy and treatment options.

conclusionsEndoscopic therapy is preferred over esophagectomy for most patients with HGD or intramucosal adenocarcinoma, and may be applicable to select patients with submucosal tumors. Clear guidelines and management algorithms will aid physicians and centers embarking on endoscopic therapy and enable a standardized approach to the management of these patients that is applicable internationally.

Indexed as

AdenocarcinomaBarrett EsophagusEsophageal NeoplasmsEsophagoscopyHumansPatient SelectionPostoperative CareSpecimen HandlingEndoscopic resectionEndotherapyEsophageal adenocarcinomaEsophagectomy

Identifiers

PMID26691147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.