ArticleScientific reports2015
Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Craniofacial Bones and Teeth in Spacefarers: Systematic Review and Meta-analysis.JDR clinical and translational research · 2023Pooled it
- Effects of 1 Gray radiation on the biophysical properties of the tibia and femur from hindlimb-suspended rats.Experimental physiology · 2026Article
- Spaceflight and the rodent skeleton: A perspective.Bone reports · 2026Review
- 37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites.PloS one · 2025Article
- Validating Causal Diagrams of Human Health Risks for Spaceflight: An Example Using Bone Data from Rodents.Biomedicines · 2022Article
- The effects of microgravity on bone structure and function.NPJ microgravity · 2022Review
- Effects of spaceflight on cancellous and cortical bone in proximal femur in growing rats.Bone reports · 2021Article
- Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites.NPJ microgravity · 2021Article
- Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading.Journal of bone and mineral metabolism · 2021Article
- Micro-CT Study of Mongolian Gerbil Humeral Bone After Prolonged Spaceflight Based on a New Algorithm for Delimitation of Long-Bone Regions.Frontiers in physiology · 2021Article
- Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Effect of Leptin Deficiency on the Skeletal Response to Hindlimb Unloading in Adult Male Mice.Scientific reports · 2019Article
- Reptiles in Space Missions: Results and Perspectives.International journal of molecular sciences · 2019Review
- Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading.Frontiers in physiology · 2019Article
- Skeletal changes during and after spaceflight.Nature reviews. Rheumatology · 2018Review
- Eight Days of Earth Reambulation Worsen Bone Loss Induced by 1-Month Spaceflight in the Major Weight-Bearing Ankle Bones of Mature Mice.Frontiers in physiology · 2018Article
- High-Resolution X-Ray Tomography: A 3D Exploration Into the Skeletal Architecture in Mouse Models Submitted to Microgravity Constraints.Frontiers in physiology · 2018Review
- One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons.Scientific reports · 2017Article
- Influence of body weight on bone mass, architecture and turnover.The Journal of endocrinology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture in weight bearing (femur and humerus) and non-weight bearing (2(nd) lumbar vertebra and calvarium) bones in the context of ovarian hormone insufficiency. 12-week-old Fisher 344 rats were ovariectomized 2 weeks before flight and randomized into one of three groups: 1) baseline (n = 6), 2) ground control (n = 12) or 3) spaceflight (n = 12). Additional ground-based ovary-intact rats provided age-matched reference values at baseline (n = 8) and landing (n = 10). Ovariectomy resulted in bone- and bone compartment-specific deficits in cancellous bone volume fraction. Spaceflight resulted in lower cortical bone accrual in the femur but had no effect on cortical bone in the humerus or calvarium. Cancellous bone volume fraction was lower in flight animals compared to ground control animals in lumbar vertebra and distal femur metaphysis and epiphysis; significant differences were not detected in the distal humerus. Bone loss (compared to baseline controls) in the femur metaphysis was associated with lower trabecular number, whereas trabecular thickness and number were lower in the epiphysis. In summary, the effect of spaceflight on bone microarchitecture in ovariectomized rats was bone-and bone compartment-specific but not strictly related to weight bearing.
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