Evidence map›Paper›PMID 26690880›Full record

ArticleThe Journal of pathology2016

Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours.

Malak S Abedalthagafi, Michael P Wu, Parker H Merrill, Ziming Du, Terri Woo, Shu-Hsien Sheu, Shelley Hurwitz, Keith L Ligon, Sandro Santagata

Abstract read
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In one paragraph

Article in The Journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Choroid Plexus Pathophysiology.Annual review of pathology · 2025
    Review
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  6. Article
  7. Review
  8. Article
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  11. Article
  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Malak S AbedalthagafiDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michael P WuDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Parker H MerrillDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ziming DuDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Terri WooDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shu-Hsien SheuDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Shelley HurwitzDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Keith L LigonDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sandro SantagataDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Pediatric Pathology Translational ResearchT32HL110852 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI FLEMING, MARK D · 2012 to 2017
$1.4M
NHLBI NIH HHS T32 HL110852
6 · The paper itself

Abstract

Well-differentiated human cancers share transcriptional programmes with the normal tissue counterparts from which they arise. These programmes broadly influence cell behaviour and function and are integral modulators of malignancy. Here, we show that the master regulator of motile ciliogenesis, FOXJ1, is highly expressed in cells along the ventricular surface of the human brain. Strong expression is present in cells of the ependyma and the choroid plexus as well as in a subset of cells residing in the subventricular zone. Expression of FOXJ1 and its transcriptional programme is maintained in many well-differentiated human tumours that arise along the ventricle, including low-grade ependymal tumours and choroid plexus papillomas. Anaplastic ependymomas as well as choroid plexus carcinomas show decreased FOXJ1 expression and its associated ciliogenesis programme genes. In ependymomas and choroid plexus tumours, reduced expression of FOXJ1 and its ciliogenesis programme are markers of poor outcome and are therefore useful biomarkers for assessing these tumours. Transitions in ciliogenesis define distinct differentiation states in ependymal and choroid plexus tumours with important implications for patient care. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Indexed as

Brain NeoplasmsCell DifferentiationChoroid Plexus NeoplasmsEpendymaEpendymomaForkhead Transcription FactorsHumansForkhead Transcription FactorsFOXJ1 protein, humanchoroid plexusciliaciliogenesisdedifferentiationependymomaFOXJ1stem cellssubventricular zone

Identifiers

PMID26690880
PMCPMC5364032

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.