ArticleSpinal cord2016
Role of neurokinin type 1 receptor in nociception at the periphery and the spinal level in the rat.
Article in Spinal cord, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
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- MRGPRX2 as a novel therapeutic target in headache.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study.Health science reports · 2026Article
- Human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry recapitulates opioid induced effects.bioRxiv : the preprint server for biology · 2025Article
- An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord.Communications biology · 2025Article
- Molecular Aspects Involved in the Mechanisms ofToxins · 2024Article
- Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains.Pathogens (Basel, Switzerland) · 2023Article
- Green Light Exposure Elicits Anti-inflammation, Endogenous Opioid Release and Dampens Synaptic Potentiation to Relieve Post-surgical Pain.The journal of pain · 2023Article
- The anti-nociceptive effect of BPC-157 on the incisional pain model in rats.Journal of dental anesthesia and pain medicine · 2022Article
- Anti-nociceptive effects of dual neuropeptide antagonist therapy in mouse model of neuropathic and inflammatory pain.The Korean journal of pain · 2022Article
- Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade.Investigative ophthalmology & visual science · 2021Article
- Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model.Cellular and molecular neurobiology · 2021Article
- Neuropathic Pain in Multiple Sclerosis and Its Animal Models: Focus on Mechanisms, Knowledge Gaps and Future Directions.Frontiers in neurology · 2021Review
- The Antiallodynic Effect of Nefopam on Vincristine-Induced Neuropathy in Mice.Journal of pain research · 2020Article
- Diverse characters of Brennan's paw incision model regarding certain parameters in the rat.The Korean journal of pain · 2019Article
- Human Dorsal Root Ganglia.Frontiers in cellular neuroscience · 2019Review
- Involvement of Neuropeptide Y in Post-Incisional Nociception in Rats.Annals of neurosciences · 2018Article
- Neuroepithelial control of mucosal inflammation in acute cystitis.Scientific reports · 2018Article
- Serum substance P: an indicator of disease activity and subclinical inflammation in rheumatoid arthritis.Clinical rheumatology · 2018Article
- Self-assembling peptide gels promote angiogenesis and functional recovery after spinal cord injury in rats.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNoxious stimuli activate small to medium-sized dorsal root ganglion (DRG) neurons. Intense noxious stimuli result in the release of substance P (SP) from the central terminals of these neurons. It binds to the neurokinin type 1 receptor (NK1r) and sensitises the dorsal horn neurons. SP is also released from the peripheral terminals leading to neurogenic inflammation. However, their individual contribution at spinal and peripheral levels to postincisional nociception has not been delineated as yet.
methodsSprague-Dawley rats were administered different doses (3-100 μg) of an NK1r antagonist (L760735) by intrathecal (i.t.) route before hind paw incision. On the basis of its antinociceptive effect on guarding behaviour, the 30 μg dose was selected for further study. In different sets of animals, this was administered i.t. (postemptive) and intrawound (i.w.). Finally, in another group, drug (30 μg) was administered through both i.t and i.w. routes. The antinociceptive effect was assessed and compared. Expression of SP was examined in the spinal cord. Intrawound concentration of SP and inflammatory mediators was also evaluated.
resultsPostemptive i.t. administration significantly attenuated guarding and allodynia. Guarding was alone decreased after i.w. drug treatment. Combined drug administration further attenuated all nociceptive parameters, more so after postemptive treatment. Expression of SP in the spinal cord decreased post incision but increased in the paw tissue. Inflammatory mediators like the nerve growth factor also increased after incision.
conclusionIn conclusion, SP acting through the NK1r appears to be an important mediator of nociception, more so at the spinal level. These findings could have clinical relevance.
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