Evidence map›Paper›PMID 26690856›Full record

ArticleSpinal cord2016

Potential variables affecting the quality of animal studies regarding pathophysiology of traumatic spinal cord injuries.

Z Hassannejad, M Sharif-Alhoseini, A Shakouri-Motlagh, F Vahedi, S A Zadegan, M Mokhatab, M Rezvan, S Saadat, F Shokraneh, V Rahimi-Movaghar

Abstract read
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In one paragraph

Article in Spinal cord, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  10. Macrophage migration inhibitory factor as a therapeutic target after traumatic spinal cord injury: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Z HassannejadSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M Sharif-AlhoseiniSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
A Shakouri-MotlaghSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
F VahediSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
S A ZadeganSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M MokhatabSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
M RezvanSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
S SaadatSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
F ShokranehCochrane Schizophrenia Group, Institute of Mental Health, University of Nottingham, Nottingham, UK.
V Rahimi-MovagharSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designThis is a Delphi study.

objectivesDefining variables that potentially influence the outcomes of an animal study regarding pathophysiology of traumatic spinal cord injury (TSCI).

settingThis study was conducted in Iran.

methodsA modified two-round Delphi study was conducted. As the first round, an initial questionnaire was developed on the basis of literature and a series of focus group discussions. In the second round, the participants were asked to score the items through a 10-point scale. Consensus was achieved through the following criteria: (1) the median of scores has to be at 7.5 or higher, and (2) at least 70% of participants need to rate 7 or higher. Also, the inter-rater reliability analysis was performed to determine consistency among raters using the Kappa coefficient and Cronbach's alpha.

resultsTwenty-one experts participated in our study. From the first round of the study, a 47-item checklist was developed. By considering the aforementioned criteria for consensus building on extremely important factors, we reached a 15-item checklist including species, strain, method and level of injury, control group, genetic background, severity of injury, attrition, use of appropriate test, blindness, method of allocation to treatments, regulation and ethics, age/weight, bladder expression, number of animals/group and statistics. The inter-rater reliability for the raters was found to be Kappa=0.82 (P<0.001). A Cronbach's alpha of 0.9 for all the questions indicated high internal consistency.

conclusionThis study introduces a checklist of variables that potentially influence the outcomes of animal studies regarding TSCI pathophysiology and describe its validity and reliability.

Indexed as

Disease Models, AnimalTrauma Severity IndicesAnimalsChecklistDelphi TechniqueFemaleHumansMaleReproducibility of ResultsSpecies SpecificitySpinal Cord InjuriesSurveys and Questionnaires

Identifiers

PMID26690856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.