Evidence map›Paper›PMID 26690810›Full record

ArticleHuman gene therapy2015

Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?

Kenneth I Berns, Barry J Byrne, Terence R Flotte, Guangping Gao, William W Hauswirth, Roland W Herzog, Nicholas Muzyczka, Thierry VandenDriessche, Xiao Xiao, Sergei Zolotukhin and 1 more

Abstract readComment
In one paragraph

Article in Human gene therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Cell and gene therapy for kidney disease.Nature reviews. Nephrology · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Evaluating the state of the science for adeno-associated virus integration: An integrated perspective.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Flies in the ointment: AAV vector preparations and tumor risk.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Article
  13. Review
  14. Evolving AAV-delivered therapeutics towards ultimate cures.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
  15. Article
  16. Review
  17. Improving Molecular Therapy in the Kidney.Molecular diagnosis & therapy · 2020
    Review
  18. Review
  19. Gene Therapy for Hemophilia: Facts and Quandaries in the 21st Century.Mediterranean journal of hematology and infectious diseases · 2020
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kenneth I Berns1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
Barry J Byrne1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
Terence R Flotte5 Office of the Dean, University of Massachusetts Medical School , Worcester, Massachusetts.
Guangping Gao6 Horae Gene Therapy Center, University of Massachusetts Medical School , Worcester, Massachusetts.
William W Hauswirth2 Genetics Institute, University of Florida College of Medicine , Gainesville, Florida.
Roland W Herzog1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
Nicholas Muzyczka1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
Thierry VandenDriessche9 Department of Gene Therapy and Regenerative Medicine, Free University of Brussels , Brussels, Belgium .
Xiao Xiao10 Department of Molecular Pharmaceutics, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Sergei Zolotukhin1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
Arun Srivastava1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.

Funding

Next Generation of Recombinant AAV Serotype Vectors for Gene TherapyR01HL097088 · NHLBI · UNIVERSITY OF FLORIDA · PI GAO, GUANGPING, HERZOG, ROLAND W. · 2010 to 2018
$5.4M
NHLBI NIH HHS R01 HL097088
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mutagenesis, InsertionalCarcinoma, HepatocellularDependovirusHumansLiver Neoplasms

Identifiers

PMID26690810
PMCPMC4809064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.